激素敏感型和耐药型肾病综合征患儿血清免疫复合物的水平及其意义  

Serum Level of Immune Complex in Children with SSNS or SRNS and Its Significance

作　　者：吴天慧[1] 李志辉[1] 段翠蓉[1] 银燕[1] 寻劢[1] 张翼[1] 

机构地区：[1]湖南省儿童医院肾内科,湖南长沙410007

出　　处：《医学临床研究》2012年第2期286-289,共4页Journal of Clinical Research

摘　　要：【目的】比较激素敏感型肾病综合征（SSNS）、激素耐药型肾病综合征（SRNS）和健康儿童血清及肾脏免疫复合物水平，评估血清免疫复合物对肾病综合征激素治疗反应性的预测作用。【方法】液相免疫沉析法检测住院病人与健康对照组血清免疫复合物水平，检测患儿肾脏免疫荧光改变，分析患儿血清免疫复合物水平与激素治疗反应性的相关性。【结果】肾病综合征患者存在血清免疫复合物的异常，IgM、IgE水平上升，IgG、IgA水平下降，SRNS更为明显，而C3、C4无明显差异，病理检查免疫荧光显示IgM阳性率较高，而SRNS相对更高，存在相关性。【结论】血清免疫球蛋白的水平是肾病综合征患者重要的血清学指标，对于临床预测激素治疗反应性有积极意义。[Objective]To compare the level of immune complex in serum and kidney among children with steroidsensitive nephrotic syndrome（SSNS）, steroidresistant nephrotic syndrome（SRNS） and healthy chil dren, and to assess the role of serum immune complex for predicting the response to steroid therapy for ne phrotic syndrome. [Methods] Serum levels of immune complexes in inpatients and healthy control were meas ured by using liquid phase immunoprecipitation. Immune fluorescence changes in kidney were detected. The relationship between serum level of immune complexes and the response to steroid therapy for nephritic syn drome was analyzed. [Results] Serum immune complexes in patients with nephrotic syndrome were abnormal. The levels of IgM and IgE in patient with nephrotic syndrome increased, while the levels of IgG and IgA de creased. The change of serum immune complexes in patients with SRNS was more obvious. The levels of C3 and C4 had no obvious change. Pathological examination showed that the positive rate of IgM was high and that in the patients with SRNS was higher. There was correlation between them. [Conclusion] Serum level of immunoglobulin is the important indicator of nephritic syndrome and has the positive significance for predicting the response to steroid therapy.

关 键 词：肾变病综合征/血液 抗原抗体复合物/血液 

分 类 号：R726.92[医药卫生—儿科]