氢化诺卜醇的合成研究  

A Study on Synthesis of Hydronopol

作　　者：赵玲华[1] 肖转泉[2] 陈金珠[3] 王宗德[1] 

机构地区：[1]江西农业大学林学院,江西南昌330045 [2]江西师范大学化学化工学院,江西南昌330027 [3]江西农业大学理学院,江西南昌330045

出　　处：《化学世界》2012年第3期163-164,168,175,共4页Chemical World

基　　金：国家自然科学基金项目(30860223;31060101);教育部留学回国人员科研启动基金项目([2010]1561);江西省青年科学家(井冈之星)培养对象计划资助项目

摘　　要：比较了由诺卜醇氢化合成氢化诺卜醇的两种方法:钠和正丁醇或异戊醇的化学还原法、镍催化的加压氢化法。气相色谱分析表明:用两种方法合成氢化诺卜醇时均有两种顺反异构体生成,且以顺式异构体为主;催化加压时,产物中的反式异构体仅占5%以下,用化学还原法时,反式异构体在产物中可达20%。从几方面考虑,合成cis-氢化诺卜醇应采用诺卜醇催化氢化法。Two synthetic methods of hydronopol from nopol were compared in this article. The two methods were chemical reduction with sodium and n-butanol or isoamyl alcohol, and pressure hydrogenation catalyzed by Raney Ni respectively. GC analysis showed that both methods would give cisand trans-isomer, and the main product was cis-isomer. Less than 5% of the product of pressure hydrogenation was trans-isomer, while near 20% trans isomer was obtained in chemical reduction method. Taking all factors into consideration, pressure hydrogenation is the appropriate method to synthesize cishydronopol.

关 键 词：诺卜醇 氢化诺卜醇 化学还原 催化氢化 合成 

分 类 号：O621[理学—有机化学] TQ351.47[理学—化学]