枯否细胞在肝移植手术后缺血再灌注损伤中的作用  

The Function of Kupffer Cell for The Ischemia Reperfusion Injury after Liver's Transplantation

作　　者：马院院[1] 李济宇[1] 

机构地区：[1]上海市新华医院普外科,上海200092

出　　处：《中国普外基础与临床杂志》2012年第3期341-345,共5页Chinese Journal of Bases and Clinics In General Surgery

基　　金：国家自然科学基金项目(项目编号:30600598);上海市科学技术委员会医学重点攻关项目(项目编号:09411952500);上海市科委青年科技启明星资助计划(项目编号:10QH1401800);上海市教育委员会曙光计划(项目编号:10SG20)~~

摘　　要：目的总结枯否细胞在肝移植术后缺血再灌注损伤中的作用。方法通过复习文献的方法对枯否细胞在缺血再灌注损伤中的作用进行综述。结果枯否细胞是肝内固有的巨噬细胞,肝移植手术后枯否细胞被激活释放一系列炎症介质,包括细胞因子、活性氧中间产物、趋化因子等,启动缺血再灌注损伤(ischemia reperfusioninjury,IRI),使移植肝失功。同时,枯否细胞不仅可以通过释放NO来减轻缺血再灌注损伤,也可以特异性的产生血红素加氧酶-1(heme oxygenase-1,HO-1)来发挥对缺血再灌注损伤的保护作用,并且有研究表明HO-1降解血红素产生的代谢产物一氧化碳(carbon monoxide,CO)也有同样的作用。结论枯否细胞在肝移植术后可以发挥双向性作用,如何减少枯否细胞释放各种有害物质,增加有利物质的表达,是今后预防移植肝后缺血再灌注损伤研究的关键。Objective To summarize the function of Kupffer cell for the ischemia reperfusion injury after liver’s transplatation.Methods The literatures which about the function of Kupffer cell for the ischemia reperfusion injury after liver’s transplatation were reviewed.Results Kupffer cells are the resident macrophages of the liver,which can be activated to generate a range of inflammatory mediators,including cytokines,reactive oxygen intermediates,chemokines,and other factors to startup the ischemia reperfusion injury（IRI）,and to cause the liver graft dysfunction.On the other hand,Kupffer cells can protect the ischemia reperfusion injury by release NO and HO-1.The CO,which is the byproduct of heme degradation by the heme oxygenases（HO-1）,has the same function for IRI.Conclusions The Kupffer cells have bidirectional function for the ischemia reperfusion injury of liver’s transpatation.Thus,how to decrease the harmful factors and up-regulate the beneficial substances by Kupffer cells will be the key points in preventing IRI after liver transplantation in future.

关 键 词：枯否细胞 缺血再灌注损伤 肝移植 

分 类 号：R657.3[医药卫生—外科学]