龙岗区常用抗菌药物用量与肺炎克雷伯菌耐药率的相关性  

The relationship between antimicrobial consumption and the rates of resistance of Klebsiela pneumoniae

作　　者：雷孝义[1] 郁相云[1] 温小丽[1] 陈广斌[2] 

机构地区：[1]深圳市龙岗中心医院药剂科,广东深圳518116 [2]深圳市龙岗区人民医院药剂科,广东深圳518172

出　　处：《中国当代医药》2012年第7期151-153,共3页China Modern Medicine

基　　金：广东省深圳市龙岗区科技局立项资助课题(项目编号:YLL2010060)

摘　　要：目的探讨深圳市龙岗区常用抗菌药物用量与肺炎克雷伯菌耐药率的相关性。方法统计2005～2010年深圳市龙岗区5个二甲医院26种常用抗菌药物平均每日每百张床位所消耗的DDDs及各类标本培养的肺炎克雷伯菌的耐药率,并对抗菌药物用量与耐药率进行相关性分析。结果肺炎克雷伯菌对头孢唑啉、氨苄西林、头孢他啶、庆大霉素、妥布霉素、环丙沙星、左氧氟沙星、复方新诺明、阿米卡星、美罗培南的耐药率与部分抗生素的用量有正相关关系(P<0.05)。结论肺炎克雷伯菌对部分抗菌药物耐药水平与部分常用抗菌药物用量之间存在正相关关系。临床必须加强抗菌药物的使用管理,规范应用抗生素。Objective To investigate the relationship between the consumption of antibacterial agents and resistance rate of Klebsiela Pneumoniae （KP） in the hospital. Methods The total antibacterial consumption, which were from 2005 to 2010 in five hospital of Longgang district, were expressed as defined daily doses （DDD）/day/100 beds, as well as resistance rate of KP were collected, and their correlation was analyzed. Results The rate of resistance of KP to Cefazolin, Ampicillin, Cef tazidime, Gentamycin, Tobramycin, Ciprofioxacin, Levofloxacin, Compound Sulfamethoxazole, Amikacin, Meropenem were significantly positivly associated with the consumption of most of antibacterial agents （P 〈 0.05）. Conclusion There is a positive correlation between the yearly antimicrobial consumption and the rates of resistance of KP. Management should be further strengthened for rational use of antibiotic agents.

关 键 词：肺炎克雷伯菌 耐药性 抗菌药物用量 相关性 

分 类 号：R978.1[医药卫生—药品]