慢性阻塞性肺疾病患者血清白细胞介素-18、单核细胞趋化蛋白-1的变化及临床意义  

The changes and clinical significance of serum IL-18 and MCP-1 in patients with chronic obstructive pulmonary disease

作　　者：黄少祥[1] 邢晓莉[1] 

机构地区：[1]天津市第五中心医院呼吸科,300450

出　　处：《中国综合临床》2012年第4期392-394,共3页Clinical Medicine of China

摘　　要：目的观察慢性阻塞性肺疾病（COPD）患者血清白细胞介素-18（IL-18）、单核细胞趋化蛋白-1（MCP-1）的表达，探讨其临床意义。方法采用病例对照研究的方法，测定COPD急性加重期（急性期组30例）、稳定期患者（稳定期组30例）及健康对照者（对照组30例）血清IL-18、MCP-1浓度，并同时测定各组血清C反应蛋白（CRP）浓度及肺功能指标[1秒钟用力肺活量（FEV。），用力呼气1秒率（FEV，）／用力肺活量（FVC）％]，进行比较及相关性分析。结果COPD急性加重期患者血清IL-18、MCP．1浓度高于稳定期[IL-18分别为（69．29±16．14）、（53．15±14．74）ng/L，MCP-1分别为（123．95±32．06）、（96．46±18．24）ng/L]，且均高于正常对照组[IL-18（37．53±14．55）ng／L，MCP-1（60．86±17．26）ng／L]，差异均有统计学意义（F值分别为10．975，18．101，P均〈0．01）；急性加重期血清IL-18、MCP-1、CRP之间呈正相关（r=0．688，P〈0．05；，=0．663，P〈0．05；r=0．825，P〈0．01），与FEVI、FCVI／FVC％呈负相关（r=-0．732，P〈0．01；r=-0．586，P〈0．05）；稳定期血MCP-1与IL-18呈正相关（r=0．674，P〈0．05），与CRP亦呈正相关（r=0．719，P〈0．05），与FEV．、FCV1／FVC％呈负相关（r=-0．512，P〈0．05；r=-0．557，P〈0．05）。结论血清IL-18、MCP．1可作为COPD患者的炎症性标志物之一,与气道炎症和气流受限有关。Objective To investigate the expression level and clinical significance of serum IL-18 and MCP-1 in patients with Chronic Obstructive Pulmonary Disease （ COPD ）. Methods Serum IL-18 and MCP-1 levels were measured in healthy people（ control group,30 cases） and in patients with COPD （acute stage group and stable stage group ,30 cases in each group） . At the same time, the level of serum CRP and forced expiratory volume in one second （ FEV1 ）, the forced expiratory volume in one second/forced vital capacity （ FEVJ FVC% ） were tested in the three groups. The variation of the level of serum IL-18 and MCP-1 and the correlation between these index with lung function and CRP were analyzed. Results The levels of serum IL-18 and MCP-1 in acute stage group （ IL-18 [ 69. 29 ± 16. 14 ] ng/L, MCP-1 [ 123.95± 32. 06 ] ng/L） were significantly higher than those in stable stage group （ IL-18 [ 53.15 ±14.74 ] ng/L, MCP-1 [ 96.46 ± 18.24 ] ng/L） （ F = 10. 975, P 〈 0. 01 ）, and also significantly higher than those in control group （ IL-18 ~ 37.53 ：e 14. 55 ] ng/L, MCP-1 [ 60. 86 ± 17.26 ] ng/L） （ F = 18. 101, P 〈 O. 01 ）. In acute stage group, positive correlations were obtained among the level of serum IL-18, MCP-1 and CRP （ r = 0. 688, P 〈 0. 05 ; r = 0. 663, P 〈 0. 05 ; r = 0. 825, P 〈 0. 01 ） , and they were correlated negatively with FEVt and FEVI/FVC% （ r = - O. 732,P 〈 0. 01 ; r = - 0. 586, P 〈 0. 05 ）. In stable stage group,the level of serum MCP-1 was correlated positively with the level of IL-18 （r = O. 674 ,P 〈 0. 05 ） and with the level of CRP（ r = 0. 719, P 〈 0.05 ）, but it was correlated negatively with FEV1 andFEV1/FVC%（r= -0.512,P〈0.05;r= -0.557,P〈0. O5）.Condusion The serumlL-18 and MCP-1 may be one of the inflammation markers in patients with COPD and may be associated with airway inflammation and limited airflow.

关 键 词：慢性阻塞性肺疾病 白细胞介素-18 单核细胞趋化蛋白-1 

分 类 号：R563.9[医药卫生—呼吸系统]