重度吸烟依赖者脑局部一致性静息态功能MRI研究  

Resting-state functional MRI on regional homogeneity changes of brain in the heavy smokers

作　　者：杨时骐[1] 吴光耀[1] 林富春[2] 孔祥泉[3] 周国锋[3] 庞浩鹏[1] 朱凌[1] 刘国兵[1] 雷皓[2] 

机构地区：[1]武汉大学中南医院MRI室,430071 [2]中国科学院武汉物理与数学研究所 [3]华中科技大学同济医学院附属协和医院放射科

出　　处：《中华放射学杂志》2012年第3期215-219,共5页Chinese Journal of Radiology

摘　　要：目的基于脑静息态功能MRI（fMRI）研究重度吸烟依赖者（HS）脑局部一致性（ReHo），探讨HS自我觉醒机制。方法选取30例Hs（Hs组）和年龄、性别匹配的31名无酒精烟草滥用健康志愿者（对照组）行3．0T静息态fMRI采集，采用统计参数图（SPM）5软件进行数据预处理，Rest软件计算ReHo值，HS组和对照组间ReHo值比较采用两样本t检验，最终获得ReHo值有统计差异的功能图。结果（1）与对照组比较，静息态下Hs组ReHo值减低脑区包括两侧楔前叶、额上回、前额叶内侧及右角回、额下回、枕下回、小脑和左额中回等。（2）与对照组比较，静息态下I-IS组ReHo值增高脑区包括两侧岛叶、海马旁回、顶叶白质、桥脑及左侧顶下小叶、舌回、丘脑、额下眶回、额颞叶白质、小脑等，且呈左侧化趋势。结论HS静息态脑默认模式网络活动减低；活动增强脑区组成吸烟成瘾静息态网络，并呈左侧化趋势，反映HS自我觉醒机制。Objective To explore the mechanism of self-awareness in the heavy smokers （HS） by using regional homogeneity （ReHo） combined with resting-state functional MRI （fMRI）. Methods Thirty HS and 31 healthy non-smokers （NS） matched for age and sex underwent a 3.0 T resting-state fMRI. The data were post-processed by SPM 5 and then the ReHo values were calculated by REST software. The ReHo values between the two groups were compared by two-sample t-test. The brain map with significant difference of ReHo value was obtained. Results Compared with that in NS group, the regions with decreased ReHo value included the bilateral precuneus, superior frontal gyms, medial prefrontal cortex, right angular gyrus, inferior frontal gyms, inferior occipital gyrus, cerebellum, and left middle frontal gynls in HS group. The regions of increased ReHo value included the bilateral insula, parahippocampal gyms, white matter of parietal lobe, pons, left inferior parietal lobule, lingual gyrus, thalamus, inferior orbital gyms, white matter of temporal-frontal lobe, and cerebellum. The difference was more obvious in the left hemisphere. Conclusions In HS, abnormal ReHo on a resting state which reflects network of smoking addiction. This method may be helpful in understanding the mechanism of self-awareness in HS.

关 键 词：吸烟 行为 成瘾 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]