Ⅲ型慢性前列腺炎患者血清IL-8、L-10、TNF-α检测的临床价值  

Clinical significance of serum IL-8,IL-10 and TNF-a levels in type III chronic prostatitis

作　　者：徐斌先[1] 陈卫国 金雷[1] 赵读泽[1] 诸玲玲[1] 

机构地区：[1]中国人民解放军第100医院泌尿外科,江苏苏州215007 [2]苏州医科大学附属第一医院泌尿外科,江苏苏州215006

出　　处：《现代泌尿外科杂志》2012年第2期167-169,共3页Journal of Modern Urology

摘　　要：目的探讨血清中细胞因子在Ⅲ型慢性前列腺炎(CP)诊断和治疗中的临床价值。方法Ⅲ型CP患者113例,平均年龄33.45岁,其中ⅢA型39例,ⅢB型74例。所有患者接受相同的治疗方案(美满霉素0.1/d,连续4周,塞来昔布200mg/d,连续4周),治疗前和治疗后4周采用ELISA法检测患者清晨血清IL-8、IL-10、TNF-α的含量,同时结合慢性前列腺炎症状评分(NIH-CP-SI)等临床资料进行分析。结果与治疗前比较,113例III型CP患者治疗4周后NIH-CPSI下降显著(38.23 vs.26.38,P<0.05),血清IL-8和TNF-α水平显著降低(P<0.01),IL-10水平则显著升高(P<0.05)。Ⅲa型CP患者与Ⅲb型CP患者血清IL-8和TNF-α水平无差别(P>0.05),后者IL-10水平升高更显著(50.1±9.3pg/mLvs.36.2±7.7pg/mL,P<0.05)。结论Ⅲ型CP存在高水平炎症反应,IL-8和TNF-a可以用于其治疗效果的评估,而IL-10的检测有助于Ⅲ型CP的分类。Objective To evaluate the significance of serum Il-8,IL-10 and TNF-a levels in the diagnosis and treatment of type III chronic prostatitis（CP）.Methods According to NIH classification system,113 cases diagnosed as type III CP were classified into two groups,39 cases of type IIIa and 74 cases of type IIIb.All patients received the same treatment： combination of 0.1/d×4 W Minocin and 200 mg/d×4 W Celebrex.NIH pain symptom index（NIH-CPSI） was compared and serum IL-8,IL-10 and TNF-a levels were measured with double antibody sandwich enzyme-linked immunocorbent assay（ELISA） before and after treatment.Results After treatment,all 113 cases showed significant decrease of NIH-CPSI（38.23 vs.26.38,P0.05）,serum IL-8 and TNF-a levels（P0.01）,but severe increase of serum IL-10 level（P0.05）.After treatment,there was no difference of serum IL-8 and TNF-a levels between type IIIa CP and type IIIb CP（P0.05）,but serum IL-10 level was higher in type IIIb CP（50.1±9.3 pg/mL vs.36.2±7.7 pg/mL,P0.05）.Conclusion Inflammatory factors play a part in the development of CP.Serum IL-8 and INF level can serve as indicators of therapeutic effects while serum IL-10 level can help to classify type III CP.

关 键 词：Ⅲ型慢性前列腺炎 细胞因子 IL-8 IL-10 TNF-Α 

分 类 号：R697.3[医药卫生—泌尿科学]