冠心宁联合硝酸甘油治疗慢性心力衰竭84例疗效观察  

Observation of curative effects on Guanxinning combined with Nitroglycerin in the treatment of 84 patients with chronic heart failure

作　　者：高永超[1] 

机构地区：[1]贵州省绥阳县人民医院,贵州绥阳563300

出　　处：《中国医药导报》2012年第7期54-56,共3页China Medical Herald

摘　　要：目的评价冠心宁联合硝酸甘油治疗慢性心力衰竭的临床疗效。方法将168例慢性心力衰竭患者随机分为治疗组与对照组各84例,对照组进行常规治疗,强心、利尿、扩血管,疗程8～14 d;治疗组在强心、利尿、扩血管的同时,给予冠心宁注射液20 mL,5%葡萄糖氯化钠液250 mL,静滴,1次/d,连用8～14 d;10%葡萄糖液250 mL+硝酸甘油10 mg,静滴,1次/d。疗程为8～14 d。监测两组患者6 min步行实验(6MWT)、左心室射血分数(LVEF)、左心室舒张末期内径(LVDD)等指标。结果治疗组患者显效51例(60.7%),有效24例(28.6%),总有效率为89.3%;对照组患者显效26例(31.0%),有效32例(38.1%),总有效率为69.0%,两组总有效率比较差异有统计学意义(P<0.05)。两组患者治疗8～14 d后,对照组治疗前后NYHA分级差异无统计学意义(P>0.05),治疗组治疗前后NYHA分级差异有统计学意义(P<0.05),且治疗组治疗后改善情况优于对照组,差异有统计学意义(P<0.05)。两组患者治疗8～14 d后LVEF和LVDD均有改善,差异有统计学意义(P<0.05),且治疗组LVEF、LVDD改善情况优于对照组,差异有统计学意义(P<0.05)。两组患者治疗8～14 d后6MWT均明显增加,差异有统计学意义(P<0.05),且治疗组6MWT改善情况优于对照组,差异有统计学意义(P<0.05)。结论在常规治疗的基础上,给予冠心宁注射液和硝酸甘油治疗慢性心力衰竭,能改善患者左室重构和心功能,提高运动耐量与生活质量。Objective To evaluate the clinical effects of Guanxinning combined with Nitroglycerin in the treatment of chronic heart failure.Methods 168 patients with chronic heart failure were randomly divided into the treatment group and the control group,with 84 patients in each group respectively.The control group was given the conventional treatment of cardiotonics,dieresis and vasodilation for 8-14 days.On the basis of cardiotonics,dieresis and vasodilation,the treatment group was given 20 mL of Guanxinning Injection and the intravenous infusion of 250 mL of 5% Dextrose Sodium Chloride Solution once a day for 8-14 continuous days,and the intravenous infusion of 250 mL of 10% Glucose Solution ＋ 10 mg of Nitroglycerin once a day for 8-14 continuous days.The 6-minute walk test（6MWT）,left ventricular ejection fraction（LVEF）,left ventricular end-diastolic diameter（LVDD） and other indicators of both groups were monitored.Results In the treatment group,51（60.7%） patients were significantly effective and 24（28.6%） were effective,with the effective rate of 89.3%.In the control group,26（31.0%） patients were significantly effective and 32（38.1%） patients were effective,with the effective rate of 69.0%.The difference between the two group was statistically significant（P 〈 0.05）.Eight to fourteen days after treatment,the difference in NYHA between before and after treatment of the control group was not significantly different（P 〉 0.05）,the difference in NYHA between before and after treatment of the treatment group was significantly different（P 〈 0.05）,and the treatment group was superior to the control group in the improvement conditions,with statistically significant difference（P 〈 0.05）.Eight to fourteen days after treatment,the LVEF and LVDD improved in both groups,with statistically significant differences（P 〈 0.05）,but the treatment group was superior to the control group in the improvement conditions of LVEF and LVDD,with statistically significant difference（P 〈

关 键 词：慢性心力衰竭 冠心宁 硝酸甘油 

分 类 号：R541.61[医药卫生—心血管疾病]