血清IGF-1和IGFBP-3及ALP在重组人生长激素治疗特发性矮小和特纳综合征中变化水平的观察  

Serum Insulin-like Growth Factor-1,Insulin-like Growth Factor Binding Protein-3 and Alkaline Phosphatase Monitoring in rhGH-treated ISS and TS Children

作　　者：王琳[1] 麻宏伟[1] 王丽波[1] 胡曼[1] 任爽[1] 谭迎花[1] 

机构地区：[1]中国医科大学附属盛京医院发育儿科,沈阳110004

出　　处：《中国医科大学学报》2012年第3期253-257,共5页Journal of China Medical University

摘　　要：目的用重组人生长激素(rhGH)治疗特发性矮小(ISS)和特纳综合征(TS)患儿,观察血清胰岛素样生长因子1(IGF-1)、胰岛素样生长因子结合蛋白3(IGFBP-3)及血碱性磷酸酶(ALP)在ISS和TS中的临床应用价值。方法对rhGH治疗的ISS患儿31例和TS患儿17例进行治疗前后血清IGF-1、IGFBP-3及ALP浓度监测,观察治疗前后的变化。结果 ISS和TS患儿经rhGH治疗后IGF-1与IGFBP-3明显升高,6个月时达高峰,之后基本维持在较高水平;IGF-1与IGFBP-3的比值治疗后显著升高(F=6.739,P<0.01),以IGF-1升高更明显;ISS和TS患儿经rhGH治疗后血清ALP也明显上升,3个月时达高峰,之后基本维持在较高水平;血清ALP与IGF-1和IGFBP-3在治疗前后各个时间段不存在显著相关性。结论 ISS和TS患儿经rhGH治疗后,血清IGF-1、IGFBP-3及ALP水平均升高,并基本维持在较高水平,IGF-1较IGFBP-3升高更为明显;治疗起始3个月血清ALP反应敏感,血清ALP尚不能作为替代IGF-1和IGFBP-3监测rhGH治疗疗效的指标。Objective To observe clinical value of serum insulin-like growth factor-1（IGF-1）,insulin-like growth factor-binding protein-3（IGFBP-3） and alkaline phosphatase（ALP） in rhGH-treated idiopathic short stature（ISS） and Turner syndrome（TS） children.Methods Serum IGF-1,IGFBP-3 and alkaline phosphatase level variation trend in rhGH-treated children,including 31 ISS and 17 TS,were monitored before and after the treatment.Results IGF-1 and IGFBP-3 level significantly increased after treatment,reach a peak after 6 months,and then IGF-1 maintenance at high level;IGF-1and IGFBP-3 ratio significantly increased after treatment;ALP level significantly increased after treatment,reach a peak after 3 months of both ISS and TS;ALP is not correlated with IGF-1 or IGFBP-3.Conclusion IGF-1,IGFBP-3 and ALP level increased after the rhGH treatment and maintenance at high level in both ISS and TS children;IGF-1 increased more than IGFBP-3;ALP was sensitive to rhGH treatment,serum ALP could not be as a parameter of monitoring efficacy of rhGH treatment.

关 键 词：重组人生长激素 胰岛素样生长因子-1 胰岛素样生长因子结合蛋白-3 血碱性磷酸酶 

分 类 号：R725.8[医药卫生—儿科]