4-氨基吡啶催化6-烷氧基取代嘌呤衍生物的合成  

Synthesis of O^6-Substituted Purine Derivatives Catalyzed by 4-Amino-pyridine

作　　者：陆鸿飞[1] 武鼎铭[1] 孙垒垒[1] 高玉华[1] 

机构地区：[1]江苏科技大学生物与化学工程学院,镇江212003

出　　处：《应用化学》2012年第4期402-409,共8页Chinese Journal of Applied Chemistry

基　　金：江苏省自然科学基金(BK2009721);江苏科技大学青年骨干教师支持计划(37060902)资助项目

摘　　要：以6-氯嘌呤为底物,4-氨基吡啶为催化剂,甲醇为溶剂合成了6-烷氧基取代嘌呤化合物。当反应条件为n(6-氯嘌呤)∶n(4-氨基吡啶)∶n(三乙胺)=10∶1∶4,回流反应5～7 h时,6-烷氧基嘌呤化合物的收率大于85%。研究表明,体系中6-氯嘌呤、4-氨基吡啶和三乙胺的相对量对反应有很大影响,用4-氨基吡啶-三乙胺混合催化剂体系催化效果更好。A series of O6-substituted purine derivatives was designed and prepared through an efficient and convenient method with 4-amino-pyridine as the catalyst in methanol solvent.Under optimized conditions： n（6-chloropurine）∶n（4-amino-pyridine）∶n（triethylamine）=10∶1∶4,refluxing for 5~7 h,the yield of 6-alkoxy purine was greater than 85%.Studies showed that,the relative amount of 6-chloropurine,4-amino-pyridine and triethylamine in the system had a great influence on the reaction,and the highest catalytic activity was achieved using a mixture of 4-amino-pyridine and triethylamine as the catalyst.

关 键 词：氨基吡啶 嘌呤 催化 烷氧基化 合成 

分 类 号：O643.5[理学—物理化学]