短期大剂量普伐他汀对急性心肌梗死患者CRP和MMP-9的影响  

Effect of large dose of pravastatin on serum CRP and MMP-9 level in patients of acute myocardial infarction

作　　者：陈英[1] 段小嬿[1] 张树锋[1] 关浩增[1] 吴相慰[1] 

机构地区：[1]广西壮族自治区江滨医院心血管三科,南宁530021

出　　处：《中国临床新医学》2012年第3期198-200,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西自然科学基金资助项目(编号:桂科自0542060)

摘　　要：目的观察较大剂量普伐他汀治疗心肌梗死患者3 d后C反应蛋白(CRP)、基质金属蛋白酶-9(MMP-9)的变化。方法 72例急性心肌梗死患者分为A、B两组,每组36例,A组口服普伐他汀片40 mg/d,B组口服普伐他汀片20 mg/d,治疗前及治疗3 d后分别测定CRP和MMP-9。结果两组患者血清CRP和MMP-9在治疗后3 d均有明显下降(P<0.05),但以40 mg普伐他汀组更明显(P<0.01)。结论急性心肌梗死早期使用普伐他汀可抑制患者炎性反应,且较大剂量效果更好。Objective To observe the effects of large does of pravastatin on the charnge of C reactive protein （CKP）, Matrix metalloproteinase-9 （MMP-9） in acute myocardial infarction patients. Methods 72 patients with acute myocardial infaction were divided into two groups ： the group A were administered orally pravastatin 40 mg/d and the group B were administered orally pravastafin 20 mg/d. The serum levels of CRP, MMP-9 were measured at the end of the treatment. Results The two groups serum levels of CRP,MMP-9 were significantly decreased at the end of the 3th day（P 〈 0. 05）, and the group A was superior to group B. Conclusion The inflammatory reaction could be inhibited in acute myocardial infarction patients treated with pravastatin.

关 键 词：心肌梗死 普伐他汀 炎性因子 

分 类 号：R542.22[医药卫生—心血管疾病]