溃结宁膏穴位敷贴治疗脾肾阳虚型溃疡性结肠炎30例临床观察  

Clinical observation on acupoint paste of kuijiening plaster in treating spleen-kidney yang deficiency syndrome of ulcerative colitis and the effect on serum IFN-r Levels

作　　者：陈昌飞[1] 朱莹[2] 

机构地区：[1]桃江县人民医院,湖南桃江413400 [2]湖南中医药大学第二附属医院,湖南长沙410005

出　　处：《中医药导报》2012年第3期19-21,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：湖南省中医药科研计划项目(2009005);长沙市科技计划项目(K0902133-31)

摘　　要：目的:观察溃结宁膏穴位敷贴治疗脾肾阳虚型溃疡性结肠炎的临床疗效及对血清IFN-r含量的影响。方法:选取60例本病患者,随机分成两组,分别给予穴位敷贴和药物内服,治疗周期为60 d。观察治疗前后两组的临床综合疗效、血清IFN-r的含量及不良反应等情况。结果:总有效率治疗组为86.7%,对照组为76.7%,两组比较,差异有统计学意义(P<0.05),治疗组优于对照组(P<0.05);两组患者治疗后血清IFN-r含量比较,差异有统计学意义(P<0.05),治疗组比对照组血清IFN-r含量下降更大。结论:溃结宁膏穴位敷贴能明显改善脾肾阳虚型溃疡性结肠炎的临床症状及肠道黏膜病变,并能降低促炎因子IFN-r的含量。Objective： To observe kuijiening plaster acupoint application for treatment of ulcerative colitis clinical observation and serum IFN-r content changes Methods： Clinical selected 60 patients with spleen and kidney yang ulcerative colitis（UC） were randomized to the observation of cases were classified into two groups,Were given point application and drug orally,the treatment period of 60 days.Before and after treatment groups of comprehensive therapeutic,mucosal neuropathy,Chinesemedicinesyndromes,serum IFN-r levels and adverse reactions.Results： KD Ning Gao Acupoint spleen and kidney yang comprehensive therapeutic effect of ulcerative colitis and SASP group rather（P0.05）;in mucosal pathological effect,mucous membrane lesions improvements,KD Ning Gao SASP significant（P0.05）,the treatment group improved TCM symptoms higher than the control group（P0.01）,on the cold limbs and waist,knees soft,bloating four individual symptom improvement than the control group（P0.05）;two groups of patients IFN-r levels were significantly reduced after treatment,with the difference statistically significant（P〈0.01）;After treatment,levels of serum IFN-r there was a significant difference（P〈0.05）Conclusion： Point Application Kuijie Ning Gao spleen and kidney yang can significantly improve the clinical symptoms of ulcerative colitis and intestinal mucosal lesions,and reduce pro-inflammatory cytokines IFN-r levels.

关 键 词：溃结宁膏 穴位敷贴 溃疡性结肠炎 IFN-R 

分 类 号：R256.34[医药卫生—中医内科学]