肺栓塞再发与血浆纤维蛋白原升高相关性研究  

Association of pulmonary embolism recurrence with increased plasma fibrinogen level

作　　者：何成[1] 江兴堂[2] 

机构地区：[1]福建医科大学研究生教育学院,福州350108 [2]厦门大学附属中山医院呼吸内科

出　　处：《国际呼吸杂志》2012年第6期417-420,共4页International Journal of Respiration

摘　　要：目的观察并评价不同血浆纤维蛋白原水平与肺栓塞再发的关系。方法回顾性分析77例初次肺栓塞患者治疗缓解后及24例肺栓塞再发患者的血浆纤维蛋白原水平，比较再发肺栓塞患者及未再发肺栓塞患者血浆纤维蛋白原水平是否存在显著差异，比较肺栓塞再发患者初次发病治疗缓解后及肺栓塞再发治疗前血浆纤维蛋白原水平之间的差异，同时分析肺栓塞再发患者栓塞灶分布与血浆纤维蛋白原升高之间的相关性。结果再次发作肺栓塞患者血浆纤维蛋白原水平高于未再次发作肺栓塞患者（P〈O．05），肺栓塞再发组治疗前血浆纤维蛋白原水平高于初次肺栓塞患者治疗缓解后血浆纤维蛋白原水平（P〈O．05），再次肺栓塞组血浆纤维蛋白原升高水平与患者的肺栓塞病灶分布无明显相关性（P〉O．05）。结论血浆纤维蛋白原升高与肺栓塞再发相关，纤维蛋白原升高是肺栓塞再发事件的重要危险因素，对肺栓塞再发有预测意义。Objective To observe and evaluate the relationship between different plasma fibrinogen levels and pulmonary embolism recurrence. Methods The plasma fibrinogen levels of 77 cases of remission in patients with initial pulmonary embolism and 24 cases of pulmonary embolism recurrence were retrospectively analyzed to observe whether there was a dominant difference plasma fibrinogen between the pulmonary embolism recurrence in patients and not recurrent pulmonary embolism in patients,to observe whether there was a dominant difference plasma fibrinogen level between pulmonary embolism recurrence of patients with initial onset of remission and pulmonary embolism recurrence with treatment, to analysis the relationship between pulmonary embolism recurrence and embolism stove distribution in patients . Results There were significant differences in plasma fibrinogen level between pulmonary embolism recurrence and not recurrence of pulmonary embolism in patients （ P d0.05）. The plasma fibrinogen level of pulmonary embolism recurrence with pre-treatment was higher than the level of plasma fibrinogen after the initial pulmonary embolism in patients with remission （ P d0.05）. There was no significant correlation between pulmonary embolism recurrence and embolism stove distribution （ P 0.05 ）. Conclusions is an important risk Elevated plasma fibrinogen is related to pulmonary embolism recurrence, fibrinogen factor for pulmonary embolism events, can predict recurrence of pulmonary embolism.

关 键 词：肺栓塞 肺栓塞再发 血浆纤维蛋白原 

分 类 号：R563.5[医药卫生—呼吸系统]