病原菌群体感应系统的研究进展  

Quorum sensing in human pathogens

作　　者：钱妩燕[1] 江涛[1] 

机构地区：[1]重庆医科大学附属第一医院呼吸内科,400016

出　　处：《国际呼吸杂志》2012年第6期425-430,共6页International Journal of Respiration

摘　　要：群体感应是细菌间依赖细胞密度的一种信息传递方式。细菌通过合成、分泌信号分子感知细菌群体密度，从而控制整个细菌群体行为。目前已在许多革兰阴性菌、革兰阳性菌和真菌中发现群体感应系统，对群体感应系统信号分子结构、信号传导通路进行大量研究后，发现其与细菌生物膜形成、生成分泌毒力因子密切相关。本文就以典型的铜绿假单胞菌、金黄色葡萄球菌、哈氏弧菌、白色念珠菌为例，对群体感应系统相关机制及研究进展予以综述。Quorum sensing is a density-dependent cell-signaling mechanism, driven by secreted signaling molecules called autoinducer. Communication enables population of cells to synchronize gene expression. Thus, quorum sensing allows groups of bacteria to act in union by perception of bacterial population density. A number of quorum sensing systems have been found in gram-negative bacteria, gram- positive bacteria and fungi, which are commonly associated with hiofilm formation and virulence. This review focuses on the lasted mechanism of quorum sensing system based on typical pathogen, including Pseudomonas aeruginosa,Staphylococcus aureus, Vibrio harveyi and Candida albicans.

关 键 词：群体感应系统 信号分子 细菌 真菌 

分 类 号：R446.5[医药卫生—诊断学]