亲环素在缺血／再灌注炎症性损伤中作用的研究进展  

Recent advances on role of cyclophilin in ischemia/reperfusion induced inflammatory injury

作　　者：王卫利[1] 薛富善[1] 廖旭[1] 

机构地区：[1]中国医学科学院北京协和医学院整形外科医院麻醉科,100144

出　　处：《国际麻醉学与复苏杂志》2012年第4期254-257,共4页International Journal of Anesthesiology and Resuscitation

摘　　要：背景 亲环素（cyclophilin，Cyp）是一类具有肽基脯氨酰顺反异构酶活性的蛋白质家族，研究表明Cyp在心肌缺血／再灌注损伤（Ischemia／reperfusioninjury，I／RI）过程中发挥着重要作用。目的分析总结有关Cyp参与I／RI发生机制的文献资料。内容简要描述Cyp家族的分子结构及生物学功能，重点阐述CypA在缺血／再灌注炎症性损伤过程中的作用机制。趋向Cyp有可能成为防治心肌I／RI的一个新靶点，新型无免疫抑制作用的Cyp配体具有十分广阔的治疗前景。Background Cyclophilins （Cyp） are a group of proteins that have peptidyl-prolyl cis-trans isomerase activity. Emerging evidences show that Cyp play an important role in the pathophysiologieal process of myocardial isehemia/reperfusion injury （URI） . Objective To review the current knowledge about the implications of Cyp in the mechanisms of FRI. Content we briefly describe the molecular structures and biological functions of Cyp, and emphatically depict the potential role of Cyp A in the process of ischemia reperfusion induced acute inflammation reaction. Trend Cyclophilins maybe become a new immunosuppressive agents target and will be probablely used for treating myocardial IJRI.

关 键 词：亲环素 缺血/再灌注损伤 炎症反应 

分 类 号：R614[医药卫生—麻醉学]