翻白草水提液对2型糖尿病胰岛素抵抗大鼠糖脂代谢的影响  

Anti-diabetic Effect of Aqueous Extract from Potentilla discolor in Type 2 Diabetic Rats

作　　者：严哲琳[1,2] 董正平[1] 孙文[1] 刘铜华[1] 

机构地区：[1]北京中医药大学,北京100078 [2]天津中医药大学方剂教研室,天津300193

出　　处：《中国实验方剂学杂志》2012年第7期216-219,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国际科技合作项目(2011DFA30920)

摘　　要：目的:观察翻白草水提取物对2型糖尿病胰岛素抵抗大鼠糖脂代谢的影响。方法:采用3周龄Wistar大鼠,高脂喂养16周加腹腔小剂量注射链脲佐菌素(STZ)的方法建立2型糖尿病胰岛素抵抗(IR)动物模型,随机分为4组:翻白草高、低剂量组(400,200 mg.kg-1)、吡格列酮组(4.05 mg.kg-1)及模型组,每组7只。另取标准饲料喂养大鼠7只为正常组。比较各药物干预4周后对2型糖尿病IR大鼠空腹血糖(FBG)、甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)及游离脂肪酸(FFA)影响。结果:翻白草提取物和西药组均可显著降低大鼠FBG,TG,TC,LDL,FFA水平,升高HDL水平(P<0.05)。结论:翻白草对2型糖尿病胰岛素抵抗大鼠的空腹血糖及血脂水平有一定调节作用。Objective：To observe the effects of aqueous extract from Potentilla discolor Bunge（APB） on blood glucose and lipids level in type 2 diabetic rat model.Method： Three week-old Wistar male rats were divided randomly into two groups according to random data table： control group with rat standard diet and model group with high-fat diet（HFD）for 16 weeks in order to induce insulin resistance and type 2 diabetic model,the HFD group was intraperitonealy given small dose STZ.Then,the model rats were divided into 4 groups： model group,positive control group（pioglitazone 4.05 mg·kg-1）,high-dose group（400 mg·kg-1） and low dose group（200 mg·kg-1） of APB aqueous extract,7 rats in each group.The control group and model group were fed with distilled water at 10 mL·kg-1.After 4 weeks of drug intervention,the fasting blood glucose（FBG）,serum triglyceride（TG）,serum total cholesterol（TC）,serum free fatty acid（FFA）,serum low-density lipoprotein（LDL-C） and serum high density lipoprotein（HDL-C） were examined.Result： Both the aqueous extract and the pioglitazone group significantly decreased FBG,TG,TC,LDL and FFA level,and increased the HDL level（P0.05）.Conclusion：Aqueous extract of P.discolor may offer an alternate treatment for diabetes by regulating fasting blood glucose and serum lipids levels in type 2 diabetic insulin resistance rats.

关 键 词：翻白草水提取物 糖尿病 血糖 血脂 胰岛素抵抗 

分 类 号：R285.5[医药卫生—中药学]