基于药物代谢酶探讨中药“十八反”配伍致毒/增毒机制  

Exploration on Mechanisms of Toxicity Caused and Enhanced by ‘Eighteen Incompatible Medicaments'of Chinese Herbs based on Drug Metabolizing Enzymes

作　　者：景欣悦[1] 彭蕴茹[1] 王新敏[1] 段金廒[1] 

机构地区：[1]南京中医药大学江苏省方剂高技术研究重点实验室,南京210046

出　　处：《中国实验方剂学杂志》2012年第7期281-285,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点基础研究发展计划(973计划)(2011CB505300-03);江苏省博士后科研计划(1002022C)

摘　　要：查阅国内外近年来有关中药"十八反"、药物代谢酶方面的文献37篇,对中药十八反配伍药物组合对细胞色素P450的影响研究现状进行分析归纳。提出中药十八反配伍对细胞色素P450影响的体内、体外研究方法与思路及现有研究方法的局限性,如体外实验不能全面反映体内实验和临床试验的结果,通过代谢酶mRNA浓度的测定不能全面反映其活性的变化等,并对今后的研究进行了展望,提出考察十八反药物对代谢酶的影响,应从体内、体外实验两方面来进行,还应结合毒性成分的代谢变化对毒性产生或增强的影响及其关联规律,进而从药物代谢酶的角度探讨十八反可能的致毒/增毒机制,为十八反配伍禁忌机制研究提供思考和借鉴。Retrieved and inspected the 37 published articles of recent years on ＇Eighteen Incompatible Medicaments＇ of Chinese herbs and CYP450 and analyzed the current situation on the impact of ＇Eighteen Incompatible Medicaments＇ of Chinese herbs based on the CYP450.The methods in vivo and in vitro for studying the impact of ＇Eighteen Incompatible Medicaments＇ on the CYP450 were put forward and the limitations of present research in methods.The in vitro study can not completely reflect in vivo and clinical research and concentration determination of mRNA of CYP450 can not overall reflect its activity were proposed.Some prospects in the study were given in order to discuss the scientific nature of ＇Eighteen Incompatible Medicaments＇based on the CYP450.Both in vivo and in vitro experiments should be conducted and the effect of toxic ingredients metabolism on the production and enhancement of toxicity should be considered.These data may supply some references for research of the mechanisms of ＇Eighteen Incompatible Medicaments＇.

关 键 词：中药十八反 细胞色素P450 毒性机制 

分 类 号：R287[医药卫生—中药学]