CD3、CD4、COX-2在非小细胞肺癌中的表达及意义  

Expression and clinical significance of CD3,CD4 and COX-2 in non-small cell lung cancer

作　　者：赵晓[1] 燕翔[1] 鞠艳芳[1] 于海明[1] 焦顺昌[1] 

机构地区：[1]解放军总医院肿瘤内科,北京100853

出　　处：《细胞与分子免疫学杂志》2012年第4期407-409,共3页Chinese Journal of Cellular and Molecular Immunology

基　　金：军队十一五医药卫生科研课题项目(06G106)

摘　　要：目的:探讨非小细胞肺癌(NSCLC)组织中CD3、CD4及环氧化酶-2(COX-2)的表达及临床意义。方法:用免疫组化法检测37例NSCLC手术标本中CD3、CD4、COX-2的表达情况,用Spearman秩和检验分析它们与患者总生存(OS)间的关系。结果:NSCLC患者组织中CD3平均面密度、CD4平均光密度均与患者OS相关(P<0.05),CD3高表达者OS较长,CD4低表达者OS更长。COX-2表达与患者术后生存时间无关(P>0.05)。结论:CD3表达越强,患者术后OS时间越长;CD4表达越强,患者术后生存时间越短;COX-2的表达强度与患者生存时间无明显相关。AIM： To study expression and clinical significance of CD3, CD4 and COX-2 in non-small cell lung cancer （NSCLC）. METHODS： Expression of COX-2, CD3 and CD4 was detected by immunohistochemical staining in 37 cases of NSCLC. The correlation of CD3, CD4, COX-2 expressions and overall survival （OS） was evaluated with spearman rank correlation analysis. RESULTS： The average surface density of CD3 and the average optical density of CD4 were significantly associated with OS of NSCLC patients after surgery （ P 〈 0.05 ）. However, both two densities of COX-2 were correlated with survival time of patients （ P 〉 0.05）. CONCLUSION： The expressions of CD3, CD4 were significantly associated with OS of NSCLC patients.

关 键 词：CD3 CD4 COX-2 非小细胞肺癌 

分 类 号：R392.12[医药卫生—免疫学]