流动注射化学发光法测定双嘧达莫  

Determination of Dipyridamole by Flow Injection Analysis with Chemiluminescence Detection

作　　者：杨敏丽[1] 李丽清[2] 封满良[3] 吕九如[3] 章竹君[3] 

机构地区：[1]宁夏大学化学科学与工程系,银川750021 [2]山东泰安师范专科学校化学系,泰安271000 [3]陕西师范大学化学系,西安710062

出　　处：《分析化学》2000年第2期161-163,共3页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金

摘　　要：采用流动注射技术研究了酸性条件下，双嘧达莫与高锰酸钾和过氧化氢的化学发光行为，对影响化学发光强度的诸因素进行了实验和探讨，建立了流动注射化学发光法测定双嘧达莫的新方法。方法的检出限为5．8×10-8g／mL，线性范围为2×10-7～8×10-5g／mL，对4×10-6g/mL双嘧达莫进行了11次平行测定，相对标准偏差为1．4％。方法用于药剂中双嘧达莫含量的测定，结果与药典标准法测得值一致。A new method for the determination of dipyridamole with flow injection chemiluminescence was described. It is based on the chemiluminescence reaction of dipyridamole-KMoO4-H2O2. The main factors which affect the determination of dipyridamole were investigated. The detection limit for dipyridamole is 5. 8 × 10-8 g/mL with a relative standard deviation of 1. 4 % for determination of 4 × 10-6 g/mL of dipyridamole(n = 11). The linear range is 2 × 10-7 ~ 8 x 10-5 g/mL. The method has been applied to the determination of dipyridamole in tablets and injections and their results are in good agreement with those obtained hy classical method.

关 键 词：双嘧达莫 化学发光 流动注射 血管扩张剂 

分 类 号：O644[理学—物理化学]