慢性阻塞性肺疾病急性加重期患者外周血Ghrelin、C反应蛋白水平变化的研究  

Study on the changes of serum ghrelin and C reactive protein(CRP) in the patients with the acute exacerbation of chronic obstructive pulmonary disease(AECOPD)

作　　者：吴玲[1] 徐贵全[1] 尘坚[1] 江映红[1] 

机构地区：[1]贵阳市第四人民医院呼吸内科,550004

出　　处：《贵州医药》2011年第12期1079-1081,共3页Guizhou Medical Journal

基　　金：贵阳市人才创业创新基金资助项目[200806]

摘　　要：目的测定慢性阻塞性肺疾病急性加重期(AECOPD)患者外周血中ghrelin、C反应蛋白水平的变化,探讨ghrelin与炎症介质C反应蛋白及AECOPD临床特点(肺功能、血气分析)的关系。方法测定AECOPD患者入院第1天、第3天、第10天外周血中的ghrelin、CRP的水平,将结果与疾病变化进行相关性研究。结果随着AECOPD疾病的缓解,治疗前、治疗中、治疗后外周血中gh-relin、CRP水平逐渐降低,治疗前后比较差异有显著性(P<0.05);氧分压P(O2)2、FEV1%上升,治疗前后比较差异有显著性(P<0.05)。ghrelin与CRP呈正相关,与P(O2)2及FEV1%呈负相关。结论 ghrelin是反映COPD病情变化的重要指标,可能通过影响患者的营养状态及炎症反应水平参与了AECOPD的发病,影响患者的预后。Objective To measure the changes of serum ghrelin and C reactive protein（CRP） in the patients with the acute exacerbation of chronic obstructive pulmonary disease（AECOPD） and discuss the correlations between ghrelin and CRP or clinical characteristics of AECOP（e.g.pulmonary function,blood gas analysis）.Methods Measure serum ghrelin and CRP at the 1st,3rd and 10th day after admission.Correlate the results with the progression of disease.Results serum ghrelin after the treatment decreased significantly compared with that before treatment（P0.05）.Arterial partial pressure of oxyge（PaO2） and FEV1% increased after the treatment（P0.05）.Ghrelin was positively correlated with CRP,but was negatively correlated with PaO2 and FEV1%.Conclusion Ghrelin is an important indicator for the progression of AECOPD.Ghrelin may be involved in the morbidity and prognostic of AECOPD through the influence on the nutrition condition and the inflammatory reaction of patients.

关 键 词：慢性阻塞性肺疾病急性加重期 GHRELIN 炎症介质C 

分 类 号：R563[医药卫生—呼吸系统]