单硫代和双硫代甘油醚在直链淀粉三(3,5-二甲基苯基氨基甲酸酯)固定相上的手性拆分  

Chiral Separation of Glycerin Monosulfides and Bisulfides with a Stationary Phase of Amylose Tris(3,5-dimethylphenylcarbamate)

作　　者：于兆文[1] 刘霞[1] 蒋生祥[1] 陈立仁[1] 

机构地区：[1]中国科学院兰州化学物理研究所,甘肃兰州730000

出　　处：《色谱》2000年第1期39-41,共3页Chinese Journal of Chromatography

基　　金：中国科学院重点基金

摘　　要：合成了直链淀粉三(3,5二甲基苯基氨基甲酸酯)手性固定相。用该固定相对6种单硫代甘油醚和4种双硫代甘油醚进行了手性拆分。单硫代甘油醚对映异构体得到了较好的分离,而双硫代甘油醚完全不能拆分。提出了样品与固定相的作用模式。Amylose tris(3,5 dimethylphenylcarbamate)(ADMPC) and aminopropylated silica gel(APS) were prepared after the reported methods. ADMPC was immobilized on APS from tetrahydrofuran solution with a coating amount of 15%. The chiral stationary phase was packed in a stainless steel column(150 mm×4.6 mm i.d.) by slurry method. The column was used for the enantioseparation of 6 glycerin monosulfides and 4 glycerin bisulfides. Mixtures of hexane and 2 propanol were used as mobile phases. The enantiomers of the monosulfides could be separated quite well, while those of the bisulfides could not at all. This phenomenon shows that the ether oxygen atom of the monosulfides plays a key role in the chiral discrimination process. The retention time of the solutes increases significantly as the amount of 2 propanol decreases. This shows the main interaction between the solutes and the chiral stationary phase is hydrogen bonding. A dynamic model is presented to account for the chiral discrimination mechanism.

关 键 词：高效液相色谱法 硫代甘油醚 手性拆分 

分 类 号：O623.423[理学—有机化学] O658.1[理学—化学]