香丹注射液心包灌洗预防心脏术后心包粘连的研究  

Preventive Effect of Xiangdan Injection on Pericardial Adhesions after Heart Surgery

作　　者：胡光柱[1,2] 张军[1] 左顺庆[1] 罗湘玉[1] 郭家龙[1,2] 

机构地区：[1]湖北医药学院附属太和医院胸心外科,湖北十堰442000 [2]湖北中医药大学

出　　处：《华南国防医学杂志》2011年第6期462-465,共4页Military Medical Journal of South China

基　　金：湖北省教育厅重点科研项目(D20092402)

摘　　要：目的探讨香丹注射液通过心包引流管灌洗预防心包粘连形成的作用及作用机制。方法 20只大耳白兔随机分为对照组及实验组(每组10只),按作者自行改良的左侧开胸手术法建立心包粘连动物模型。对照组灌洗用药为生理盐水;实验组灌洗用药为香丹注射液(4%浓度),干预药物均通过心包引流管注入心包腔灌洗治疗。对纤维粘连蛋白指标检测并统计分析,同时观察心包病理形态的变化。结果实验组在给药3天后各纤维粘连指标与对照组相比有统计学差异;病理组织学观察两组粘连程度有显著区别,实验组心包粘连程度较轻。结论香丹注射液具有降低心包腔内纤维粘连蛋白浓度的作用,中药治法对预防术后心包粘连形成具有重要意义。Objective To study the preventive effect and mechanism of Xiangdan injection on pericardial adhesions.Methods Twenty Japanese flap-eared white rabbits were randomly divided into control group and experiment group（n=10 each）.The rabbit models with pericardial adhesions were established by the improved left-sided surgical approach presented by the authors.Experiment group received Xiangdan injection of 4% concentration by pericardial cavity perfusion.Control group received normal saline injection.The levels of fibronectin（FN） in the pericardial cavity were measured and statistically analyzed.The pathological and morphological changes of the pericardium were observed.Results After three days of drug administration,the FN levels were significantly different between the two groups.The pathological and morphological observation indicated significant difference in the pericardial adhesion degrees,which was lighter in experiment group.Conclusion Xiangdan injection can decrease the FN concentration in the pericardial cavity.The traditional Chinese drug is important to prevent the pericardial adhesions after surgery.

关 键 词：香丹 心包粘连 预防作用 

分 类 号：R259.414[医药卫生—中西医结合]