鬼臼毒素及其衍生物的单电子还原电位测定  

Determination of One-electron Reduction Potentials of Podophyllotoxin and Its Derivatives by Pulse Radiolysis

作　　者：汪世龙[1] 王玫 孙晓宇 张超杰 马秀文 倪亚明 姚思德[2] 王文峰[2] 

机构地区：[1]同济大学测试中心,上海200092 [2]中国科学院上海原子核研究所辐射化学开放研究实验室,上海201800

出　　处：《高等学校化学学报》2000年第1期66-69,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金! (批准号 :3970 0 0 2 9)资助

摘　　要：采用脉冲辐解技术 ,杜醌作参比物 ,通过改变鬼臼毒素、去甲表鬼臼毒素和 VP-1 6的浓度 ,控制其阴离子向杜醌电子转移的速度 ,测得了鬼臼毒素、去甲表鬼臼毒素和 VP-1 6的单电子还原电位分别为 -3 1 0 ,-3 3 9和 -3 3 4m V,揭示了鬼臼毒素及其衍生物作为抗肿瘤药物的辐射增敏机理 .One-electron reduction potential is one of the important parameters of radiosensitive compound with a high electron affinity. In this work one-electron reduction potentials of podophyllotoxin and its derivatives were determined by pulse radiolysis using duroquinone as references. The one-electron reduction potentials of podophyllotoxin, 4-demethylepipodophyllotoxin(DMEP) and etoposide (VP-16) are -310 mV, -339 mV, -334 mV, respectively.

关 键 词：鬼臼毒素 脉冲辐解 单电子还原电位 抗肿瘤药物 

分 类 号：R979.1[医药卫生—药品] R914.4[医药卫生—药学]