NAD(P)H模型引发的还原环化2,2-双取代1,2-二氢茚的合成  

Reductive Cyclization Initiated by an NAD(P)H Model Synthesis of 2,2-Disubstituted Indanes

作　　者：王宏义[1] 刘有成[1] 郭庆祥[2] 

机构地区：[1]兰州大学应用有机化学国家重点实验室,化学系兰州730000 [2]中国科学技术大学化学系,合肥230026

出　　处：《高等学校化学学报》2000年第1期79-81,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金! (批准号 :2 9832 0 4 0 )资助

摘　　要：A facile synthesis of 2,2-disubstituted idanes was achieved by the reductive cyclization of 1-(o-bromomethylphenyl)-2,2-disubstituted-ethylenes(electron-withdrawing substituents) with an NAD(P)H model, 1-benzyl-1,4-dihydronicotinamide, in yields from moderate to good. The study revealed that \{1-benzyl\}-1,4-dihydronicotinamide can be used in synthetic organic chemistry as an effective reductant.A facile synthesis of 2,2-disubstituted idanes was achieved by the reductive cyclization of 1-(o-bromomethylphenyl)-2,2-disubstituted-ethylenes(electron-withdrawing substituents) with an NAD(P)H model, 1-benzyl-1,4-dihydronicotinamide, in yields from moderate to good. The study revealed that \{1-benzyl\}-1,4-dihydronicotinamide can be used in synthetic organic chemistry as an effective reductant.

关 键 词：NAD(P)H模型 还原环化 茚 合成方法 

分 类 号：O625.159[理学—有机化学]