手性化合物在质谱中光学稳定性的研究  

Studies on the Optical Stability of Chiral Compounds in EI Mass Spectrometry Process

作　　者：吴忆南[1] 潘远江[1] 陈耀祖[1] 

机构地区：[1]浙江大学化学系,杭州310027

出　　处：《高等学校化学学报》2000年第1期88-90,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金! (批准号 :2 980 50 0 2 )资助

摘　　要：The optical stability of chiral 2-hydroxy-2-phenylacetic acid in electron ionization mass spectrometry(EIMS) process has been detected directly by deuterium labelling technique. From the EI mass spectrum of deuterated 2-hydroxy-2-phenylacetic acid, the major characteristic fragment ion at m/z 108(the capture of the carbonyl group) and the corresponding isotopic ion(13C) at m/z 109 can be observed, and the ratio of m/z=109 to m/z=108 is about 8%(the calculated value is 7.8%). As enolization of deuterated 2-hydroxy-2-phenylacetic acid in mass spectrometry can yield the characteristic fragment ion at m/z 109 and results in much higher ratio of 109/108 than 8%; this study shows that no enolization takes place during the EI-MS process of 2-hydroxy-2-phenylacetic acid. This results can be concluded that these compounds are optically stable in the process of instantaneous vaporization at high temperature and electron impact ionization.The optical stability of chiral 2-hydroxy-2-phenylacetic acid in electron ionization mass spectrometry(EIMS) process has been detected directly by deuterium labelling technique. From the EI mass spectrum of deuterated 2-hydroxy-2-phenylacetic acid, the major characteristic fragment ion at m/z 108(the capture of the carbonyl group) and the corresponding isotopic ion(13C) at m/z 109 can be observed, and the ratio of m/z=109 to m/z=108 is about 8%(the calculated value is 7.8%). As enolization of deuterated 2-hydroxy-2-phenylacetic acid in mass spectrometry can yield the characteristic fragment ion at m/z 109 and results in much higher ratio of 109/108 than 8%; this study shows that no enolization takes place during the EI-MS process of 2-hydroxy-2-phenylacetic acid. This results can be concluded that these compounds are optically stable in the process of instantaneous vaporization at high temperature and electron impact ionization.

关 键 词：手性化合物 光学稳定性分析 质谱过程 

分 类 号：O641.6[理学—物理化学] O621.22[理学—化学]