阿托伐他汀治疗慢性充血心力衰竭疗效观察  

Observation on the therapeutic effect of Atorvastatin in treating congestive heart failure

作　　者：徐爱琴 程丽萍 

机构地区：[1]铜陵有色职工总医院心内科,安徽244000

出　　处：《齐齐哈尔医学院学报》2012年第2期189-190,共2页Journal of Qiqihar Medical University

摘　　要：目的观察阿托伐他汀治疗慢性充血心力衰竭的疗效。方法选取2009年4月～2011年4月治疗的60例慢性充血性心力衰竭患者随机分为治疗组(30例)和对照组(30例)。两组患者均进行慢性充血性心力衰竭的常规治疗,治疗组患者在常规治疗的基础上加用阿托伐他汀20mg,1次/d,口服,疗程3个月,观察两组患者治疗前后左室射血分数(LVEF)、6分钟步行距离(6-MWD)、左室舒张末内径(LVDD)、左室收缩末内径(LVSD),并观察患者的不良反应。结果经过3个月的治疗,治疗组患者的左室射血分数(LVEF)和6分钟步行距离(6-MWD)增加(P<0.05),左室舒张末内径(LVDD)和左室收缩末内径(LVSD)减小(P<0.05),与对照组患者相比差异有统计学意义。结论阿托伐他汀能改善慢性充血心力衰竭疗效患者的心功能。Objective To observe therapeutic effect of Atorvastatin in patients with chronic con gestive heart failure. Methods During Apr. 2009Apr. 2011, 60 patients with chronic congestive heart failure were randomly divided into two groups： the treatment group （n：30）,who received Atorv astatin 20mg one time every night, and the control group （n： 30）. All patients were treated by normal basic therapy. The time of therapy was 3 months. Left ventricular ejection fraction （LVEF）, 6minute walk distance （6MWD）, left ventricular end diastolic diameter （LVDD）, and left ventricular end sys tolic diameter （LVSD） of the patients were observed before and after the treatment, and the patients ad verse reactions were observed at the same time. Results After treatment of three months, in the treat ment group, left ventricular ejection fraction （LVEF） and 6 minute walk distance （6 MWD） in creased （P~ 0.05）, while left ventricular end diastolic diameter （LVDD） and left ventricular end systolic diameter （LVSD） decreased （P ~ 0.05）. Conclusions Atorvastain can improve heart function of pa tients with chronic congestive heart failure.

关 键 词：阿托伐他汀 充血性心力衰竭 心功能 

分 类 号：R969.4[医药卫生—药理学]