冬胃颗粒治疗寒凝气滞与寒凝血瘀型慢性胃炎疗效观察  

Dongwei Granule in treatment of chronic gastritis with cold obstruction causing qi stagnation and cold obstruction causing blood stasis:a randomized parallel controlled clinical trial

作　　者：于丽[1] 陈晶[1] 林一帆[1] 赵明宏[2] 陆宇平[1] 高文艳[1] 巩阳[1] 刘杨[1] 季芳[1] 李昊燃[1] 雷春红[1] 

机构地区：[1]沈阳军区总医院中医科国家中西医结合消化病重点专科,辽宁沈阳110015 [2]沈阳军区总医院药剂科,辽宁沈阳110015

出　　处：《中国中西医结合消化杂志》2012年第3期112-115,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：军队"十二五"中医药专项重点课题基金(10ZYZ102)

摘　　要：[目的]观察冬胃颗粒治疗寒凝气滞与寒凝血瘀型慢性胃炎的临床疗效及安全性。[方法]86例寒凝气滞与寒凝血瘀型慢性胃炎患者随机分为2组,试验组(43例)给予冬胃颗粒8g,3次/d,对照组(43例)给予铝碳酸镁片0.5g,3次/d,2药均于两餐间及睡前服用,疗程为2周,观察各组第1、3、7、14天腹痛腹胀、泛酸、嗳气与纳差症状缓解情况,同时观察其安全性。[结果]2组患者均有一定疗效,但冬胃颗粒治疗后第1、3、7、14天患者腹痛腹胀、嗳气、纳差症状疗效指标的评价均优于铝碳酸镁(P<0.01),虽然在第1、3天,泛酸症状疗效指标显示铝碳酸镁略优于冬胃颗粒,但差异无统计学意义(P>0.05),在第7、14天,冬胃颗粒对泛酸症状疗效指标评价优于铝碳酸镁(P<0.01),以有序logistic模型重复测量GEE分析方法,多点综合重复评价,冬胃颗粒对泛酸症状疗效指标评价优于铝碳酸镁(P<0.01)。且未见不良反应。[结论]冬胃颗粒可有效防治寒凝气滞与寒凝血瘀型慢性胃炎,缓解症状快,且无不良反应。[Objective]To evaluate the clinical efficacy and safety of Dongwei Granule on chron- ic gastritis with cold obstruction causing qi stagnation （COCQS）and cold obstruction causing blood stasis（COCBS）. [Methods]Eighty-six patients of chronic gastritis with COCQS and COCBS were selected for a randomized parallel controlled trial. The 43 cases in the study group were treeted with Dongwei Granule 8g rid for seven days,while another 43 in the control group were given hydrotalcite 0. 5g rid, and then the clinical efficacy and safety were investigated. [Results]Both groups have some curative effect, however, the evaluation of curative effect of Dongwei Granule in ab- dominal pain, belching, anorexia at day 1,3,7, 14 gained an advantage over that of hydrotaleite （P〈0. 01）. Although the effect of hydrotalcite in water brash was slightly superior to that of Dongwei Gran- ule at day 1 and 3, there was no statistical significance （P = 0. 5359,0. 7318）, and the latter had better effect than the former at day 7 and day 14（P〈0. 01）. The evaluation of curative effect of Dongwei Granule in water brash gained an advantage over that of hydrotalcite（P〈0. 01）by the analytical method of lo- gistic model duplicate measurement, no obvious side effects were found. [Conelusion]Dongwei Granule could effectively prevent and cure chronic gastritis with COCQS and COCBS and quickly relieve the symptoms.

关 键 词：胃炎 寒凝气滞 寒凝血瘀 冬胃颗粒 铝碳酸镁片 

分 类 号：R573.3[医药卫生—消化系统]