Preparation of(R)-2-chloro-1-(m-chlorophenyl)ethanol by Lipozyme TL IM-catalyzed second resolution  

作　　者：Shi Wen Xia Hui Lin Yong Zheng Chen 

机构地区：[1]College of Bio-information,Chongqing University of Posts and Telecommunications,Chongqing 400065,China [2]Chengdu Institute of Biology,Chinese Academy of Sciences,Chengdu 610041,China [3]Department of Pharmacy,Zunyi Medical College,Zunyi 563003,China

出　　处：《Chinese Chemical Letters》2012年第3期289-292,共4页中国化学快报（英文版）

基　　金：support from the National Natural Science Foundation of China(No20672110)

摘　　要：（R）-2-Chloro-l-（m-chlorophenyl）ethanol,a precursor of（R）-3-chlorostyrene oxide which is the key chiral intermediate for the preparation of severalβ3-adrenergic receptor agonists was prepared in 40%yield and 99%ee by the Lipozyme TL IM-catalyzed second resolution of the corresponding racemate in the presence of vinyl acetate.（R）-2-Chloro-l-（m-chlorophenyl）ethanol,a precursor of（R）-3-chlorostyrene oxide which is the key chiral intermediate for the preparation of severalβ3-adrenergic receptor agonists was prepared in 40%yield and 99%ee by the Lipozyme TL IM-catalyzed second resolution of the corresponding racemate in the presence of vinyl acetate.

关 键 词：（R）-2-Chloro-1-（m-chlorophenyl）ethanol LipozymeTL IM Enzymatic transesterification Vinyl acetate Second resolution 

分 类 号：TQ463.2[化学工程—制药化工] TS221[轻工技术与工程—粮食、油脂及植物蛋白工程]