A new isocoumarin from metabolites of the endophytic fungus Alternaria tenuissima(Nees & T.Nees:Fr.) Wiltshire  

作　　者：Zhen Feng Fang Shi Shan Yu Wan Qi Zhou Xiao Guang Chen Shuang Gang Ma Yong Li Jing Qu 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China

出　　处：《Chinese Chemical Letters》2012年第3期317-320,共4页中国化学快报（英文版）

基　　金：Financial support from the National Science and Technology Project of China(No2009ZX09311-004);the Natural Science Foundation of China(No201072234)

摘　　要：A new isocoumarin,tenuissimasatin（1）,was isolated from metabolites of the endophytic fungus Alternaria tenuissima（Nees ＆ T.Nees：Fr.） Wiltshire,which was isolated from the bark of Erythrophleum fordii Oliver,together with 11 known compounds（2- 12）.The structure and absolute configuration of 1 was determined by means of NMR and CD analysis.Compound 3 shows selective cytotoxic activity on human colon cancer cell HCT-8（IC_（50） = 1.78μmol/L） by MTT test in vitro.Other compounds show no such activities（IC_（50）〉10μmol/L）.A new isocoumarin,tenuissimasatin（1）,was isolated from metabolites of the endophytic fungus Alternaria tenuissima（Nees ＆ T.Nees：Fr.） Wiltshire,which was isolated from the bark of Erythrophleum fordii Oliver,together with 11 known compounds（2- 12）.The structure and absolute configuration of 1 was determined by means of NMR and CD analysis.Compound 3 shows selective cytotoxic activity on human colon cancer cell HCT-8（IC_（50） = 1.78μmol/L） by MTT test in vitro.Other compounds show no such activities（IC_（50）〉10μmol/L）.

关 键 词：Endophytic fungus Alternaria tenuissima（Nees ＆ T.Nees：Fr.） Wiltshire Tenuissimasatin 

分 类 号：Q949.32[生物学—植物学] TQ466.9[化学工程—制药化工]