老年冠心病小血管置入EXCEL支架的安全性与有效性  

Outcomes of percutaneous coronary intervention with EXCEL stents for elderly patients with small vessel coronary artery disease

作　　者：张华[1] 孙书红[1] 张磊[1] 杨星昌[1] 马兰香[1] 惠增骞[1] 丁守良[1] 赵妮[1] 韩雅玲[2] 

机构地区：[1]武警陕西总队医院心脏中心,西安710054 [2]沈阳军区总医院全军心血管病研究所心内科,沈阳110016

出　　处：《武警医学》2012年第3期217-220,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的观察老年冠心病患者小血管置入国产EXCEL支架的安全性与有效性。方法本研究对老年冠心病患者单纯置入小血管支架(支架直径<3.0 mm,297例)和单纯置入大血管支架(直径≥3.0 mm,405例)进行对比分析,术后6、12、18个月进行随访,观察临床不良事件(major adverse cardiac events,MACE)发生情况及血栓发生率。结果 6～18个月时两组间MACE事件、靶病变血运重建(target lesion revascularization,TLR)、心源性病死率差异无统计学意义,但非致命性急性心肌梗死(myocardial infarction,MI)及累计血栓事件老年小血管支架组较大血管组增加(P<0.05)。结论老年冠心病患者小血管内置入国产EXCEL比同龄大血管冠心病患者血栓累计发生率高。Objective To assess the efficacy and safety of percutaneous coronary intervention with EXCEL stents for elderly patients with small vessel coronary artery disease.Methods Patients were assigned into small stent group（3 mm,297patients） and larger stent group（≥3 mm,405 patients）.The pre-specified primary outcome was the rate of major adverse cardiac events（MACE） at 6,12 and 18 months.Results At 6 to 18 months,there was no significant difference between the two groups in MACE,stent thrombosis or Cardiac death（P0.05）.The small stent group had higher stent thrombosisrate than the large stent group（P0.05）.Conclusions This study demonstrates not only the clinical safety and efficacy of biodegradable polymer based sirolimus-eluting stents.in elderly patients with small vessel coronary artery disease,but also a higher stent thrombosis rate in the long-term outcome.

关 键 词：小血管 EXCEL支架 经皮冠状动脉介入治疗 

分 类 号：R543.3[医药卫生—心血管疾病]