高血压脑出血后血浆脂联素浓度变化及其与炎症因子相关性研究  

The change of plasma adiponectin level and its correlation with inflammatory cytokines after hypertensive cerebral hemorrhage

作　　者：王宏[1] 王文宏[1] 游洋[1] 苏正[1] 

机构地区：[1]东南大学医学院附属中大医院神经外科,江苏南京210009

出　　处：《南京医科大学学报（自然科学版）》2012年第3期378-381,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省自然科学基金资助(BK2010419)

摘　　要：目的:高血压脑出血后血浆脂联素浓度变化及其与炎症因子相关性研究。方法:选择43例脑出血患者及30例对照组患者,用酶联免疫法检测其入院后第1、2、3、5、7天的血浆脂联素浓度及入院时白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)浓度,放射免疫法检测高敏C-反应蛋白(CRP)浓度,分析高血压脑出血后血浆脂联素与炎症因子之间的相关性。结果:患者脑出血后,血浆脂联素浓度在6 h内明显升高,在24 h达高峰,持续2 d后逐渐下降。实验组血浆脂联素浓度、CRP、IL-6及TNF-α均不同程度高于对照组。相关分析显示血浆脂联素浓度与炎症因子之间呈正相关。结论:高血压脑出血患者血浆脂联素呈动态变化过程,且可能与CRP、IL-6及TNF-α共同参与了脑出血后的炎症反应,是脑出血后脑组织损伤的重要机制之一。Objective：To detect the change of plasma adiponectin and its correlation with inflammatory cytokines after hypertensive cerebral hemorrhage.Methods： Blood samples of 30 cases in control group and 43 patients with hypertensive cerebral hemorrhage were obtained 1,2,3,5,and 7 days after hospitalization.Enzyme-linked immunosorbent assay（ELISA） and radioimmunoassay were used to measured concentrations of plasma adiponectin,interleukin-6（IL-6）,C-reactive protein（CRP） and tumor necrosis factor-α（TNF-α）.Results： After hypertensive cerebral hemorrhage,the level of plasma adiponectin increased immediately within 6 h,reached the peak at 24 h,and decreased gradually after 2 days.The adiponectin concentration was higher in patients with hypertensive cerebral hemorrhage than control group during 7 days.The levels of plasma IL-6,CRP,and TNF-α in patients with hypertensive cerebral hemorrhage were significantly higher than those in control group,and were associated with adiponectin level.Conclusion： The change of plasma adiponectin was a dynamic process.Together with IL-6,CRP,and TNF-α,plasma adiponectin may be involved in the inflammatory responses injury after cerebral hemorrhage.

关 键 词：血浆脂联素 高血压脑出血 高敏C-反应蛋白 白介素-6 肿瘤坏死因子-Α 

分 类 号：R544.1[医药卫生—心血管疾病]