胎儿生长发育与脐血促肾上腺皮质激素及皮质醇的关系  

Studies on the relations between fetal growth and cord blood ACTH and crotisol

作　　者：王旭[1] 朱子阳[1] 石星[1] 

机构地区：[1]南京医科大学附属南京儿童医院内分泌科。江苏南京210008

出　　处：《南京医科大学学报（自然科学版）》2012年第3期411-413,共3页Journal of Nanjing Medical University(Natural Sciences)

基　　金：南京医科大学科技发展基金面上项目资助(08NMUM043)

摘　　要：目的:研究促肾上腺皮质激素(ACTH)、皮质醇(Cor)与胎儿生长发育的相关性。方法:根据出生体重与胎龄的关系将新生儿分为3组:小于胎龄儿(SGA组)30例、大于胎龄儿(LGA组)30例、适于胎龄儿(AGA组)30例,分别测定出生时身长、体重,放射免疫法测定脐血ACTH以及Cor水平。结果:脐血ACTH水平分别为:LGA组(26.46±7.73)ng/ml、AGA组(28.64±7.12)ng/ml、SGA组(29.30±8.33)ng/ml,三组间比较无显著差异(P=0.336),脐血Cor水平分别为LGA组(7.11±2.70)ng/ml、AGA组(11.84±3.88)ng/ml、SGA组(18.80±5.27)ng/ml,三组间比较:SGA组>AGA组>LGA组,各组间比较差异均有统计学意义(P<0.01)。结论:血清Cor与胎儿生长发育相关,对生长发育起调节作用。Objective：To investigate the relationship between fetal growth and cord blood adrenocorticotropic hormone（ACTH） and crotisol.Methods： The newborns were divided into three groups according to their born weight and gestational age,small for gestational age（SGA group,n = 30）,lager for gestational age（LGA group,n = 30）,appropriate gestational age（AGA group,n = 30）.Born body length and body weight of three groups were measured respectively.The levels of ACTH and crotisol in cord blood were measured by radioimmunoassay（RIA）.Results： The levels of ACTH in cord blood were（26.46 ± 7.73） ng/ml,（28.64 ± 7.12） ng/ml and（29.30 ± 8.33） ng/ml in LGA group,AGA group and SGA group respectively,and there were no significant differences among three groups（P = 0.336）.The levels of crotisol in cord blood were（7.11 ± 2.70） ng/ml,（11.84 ± 3.88） ng/ml and（18.80 ± 5.27） ng/ml in LGA group,AGA group and SGA group respectively,and there were significant differences among three groups（P 0.01）.Conclusion： Crotisol might play an important role in fetal growth.

关 键 词：促肾上腺皮质激素 皮质醇 新生儿 

分 类 号：R714.51[医药卫生—妇产科学]