基于多元数据分析研究中药制剂原料吸湿性与其他物理特性的相关性  

Multivariate analysis of relationships between material properties and hygroscopicity of Chinese medicine raw materials

作　　者：赵立杰[1] 冯怡[1] 徐德生[2] 阮克锋[1] 洪燕龙[1] 付小菊[1] 

机构地区：[1]上海中医药大学中药现代制剂技术教育部工程研究中心,上海201203 [2]上海中医药大学附属曙光医院,上海200021

出　　处：《药学学报》2012年第4期517-521,共5页Acta Pharmaceutica Sinica

基　　金：国家科技重大专项资助项目(2009ZX09502-009);上海市自然科学基金资助项目(10ZR1430200);上海高校选拔培养优秀青年教师科研专项基金资助项目(Szy09015);上海市教委重点学科资助项目(J50302)

摘　　要：测定16种中药制剂原料的吸湿特性参数和物理特性参数,采用主成分分析和偏最小二乘回归分析中药制剂原料的吸湿行为以及中药制剂原料的吸湿性与其他物理特性的关系。结果表明,含水量、粒径分布、水溶特性和黏聚力与平衡吸湿量、吸湿初速度、吸湿加速度均有较好的相关关系。其中平衡吸湿量与含水量、粒径分布、水溶特性和黏聚力呈正相关;吸湿初速度与含水量、粒径分布、凸起度呈负相关,与水溶特性和黏聚力呈正相关;吸湿加速度与含水量、粒径分布呈正相关,与水溶特性和黏聚力呈负相关。从物理因素角度分析了中药制剂原料的吸湿特性。Material properties and hygroscopicity were determined. Principal component analysis and partial least squares regression were applied to evaluate relationships between material properties and hygroscopicity of Chinese medicine raw materials. The results showed that hygroscopicity was corrdated with water content, particle size distribution, water soluble characteristic and cohesion. Balanced moisture content was positively correlated with water content, particle size distribution, water soluble characteristic and cohesion. Moisture absorption velocity was negatively correlated with particle size distribution, protruding degree and positively correlated with water soluble characteristic and cohesion. Moisture absorption acceleration was positively correlated with water content, particle size distribution and negatively correlated with water soluble characteristic and cohesion. Hygroscopicity of Chinese medicine raw materials is interpreted in terms of physics.

关 键 词：中药提取物 吸湿性 主成分分析 偏最小二乘回归 

分 类 号：R943[医药卫生—药剂学]