两种不同提取方法所得鹰嘴豆总皂苷对2型糖尿病大鼠肾脏功能的影响  

Effects of two different extracts of total saponins from Cicer arietinum on kidney of T2DM rats

作　　者：凯赛尔·阿不都克热木[1,2] 魏媛媛[3] 李潇[1] 闫冬[1] 阿吉艾克拜尔·艾萨[4] 帕尔哈提·克热木[1] 

机构地区：[1]新疆医科大学药理学教研室,新疆乌鲁木齐830011 [2]新疆维吾尔自治区维吾尔医药研究所,新疆维吾尔医方剂学重点实验室,新疆乌鲁木齐830049 [3]新疆医科大学生理学教研室,新疆乌鲁木齐830011 [4]中国科学院新疆理化技术研究所,新疆乌鲁木齐830011

出　　处：《药学学报》2012年第4期541-545,共5页Acta Pharmaceutica Sinica

基　　金：新疆维吾尔自治区自然科学基金资助项目(200821109);中国科学院西部行动高新技术项目计划(KGCX2-YW-503)

摘　　要：糖尿病肾病（diabetic nephropathy,DN）的发病机制迄今尚未完全明了,目前认为与糖脂代谢紊乱、血流动力学的改变、遗传因素、氧化应激、血管活性物质等多种因素有关。鹰嘴豆（Cicer arietinum L.）在维吾尔医药中已有两千多年应用历史,为一年生栽培植物,维吾尔语称其为诺胡提（音译）。鹰嘴豆属于高营养豆类植物,具有较高的药用价值。据《维吾尔常用药材》记载,鹰嘴豆具有主消渴、解百毒、润肺止咳等功效。Protective effects of two different extracts of TSCA（total saponins from Cicer arietinum） were studied on kidney of T2DM rats.The diabetic model group was established with high calorie feeding and small dose injection of streptozotocin（STZ,45 mg·kg-1）.DM rats were randomly assigned to model group（feed with propylene glycol 1 mL/100 g）,TSCA high dose group（300 mg·kg-1）,TSCA low dose group（100 mg·kg-1） and normal control group（feed with propylene glycol 1 mL/100 g）.After four weeks treatment with TSCA I and II,the levels of FPG,FIns,BUN,Scr,ATII,ET-1,TXB2 and 6-keto-PGF1α in blood and the activities of SOD,GSH-PX and MDA in kidney were analyzed by biochemical methods.After four weeks treatment with TSCA II,the levels of FPG,FIns,BUN,Scr,ATII and ET-1 were reduced significantly;and the ratios of TXB2 to 6-keto-PGF1α and SOD were effectively alleviated in TSCA II group.While there is no significant change on FPG and BUN in comparison to the rats treated with TSCA I,Scr,ATII,ET-I,GSH-PX and SOD were alleviated.The results suggest that TSCA II could be used to reduce FPG and FIns.According to the result of vasoactive substances index,TSCA II is more effective than TSCA I on renal protection of DM rats.

关 键 词：鹰嘴豆总皂苷 2型糖尿病 肾功能 血管活性物质 抗氧化作用 

分 类 号：R965[医药卫生—药理学]