首发精神分裂症患者客体旋转的正镜像差异及其事件相关电位研究  

Event-related potentials and the mirror-normal differences of object rotation in first-episode schizophrenia

作　　者：陈玖[1] 杨来启[1] 陈永雄[2] 李兰兰[1] 刘光雄[1] 张彦[1] 吴兴曲[1] 马文涛[1] 邓自和[1] 

机构地区：[1]中国人民解放军第三医院全军精神病防治中心,宝鸡721004 [2]中国人民解放军第三医院麻醉科

出　　处：《中华行为医学与脑科学杂志》2012年第3期209-211,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：军队中医药科研专项课题（IOZYX108）

摘　　要：目的探讨首发精神分裂症患者客体旋转的脑电生理机制。方法对来自解放军第三医院的30例精神分裂症患者和28例健康被试进行客体旋转任务的事件相关电位（event-relatedpotential，ERP）测定。测量P500的潜伏期、波幅及其错误数和反应时。结果与对照组[正像：（494．16±34．68）ms、（9．56±2．54）μV；镜像：（496．51±33．10）ms、（6．38±2．41）μV]相比，患者组正像和镜像潜伏期延迟[正像：（571．30±51．21）ms；镜像：（573．41±39．27）ms]、波幅降低[正像：（4．26±1．01）μV；镜像：（3．61±1．21）μV]，均差异有统计学意义（P〈0．05）。2组潜伏期正像与镜像均差异无统计学意义（P〉0．05）；患者组波幅正像与镜像差异无统计学意义（P〉0．05），对照组正像波幅高于镜像，差异有统计学意义（P〈0．05）。结论首发精神分裂症患者心理旋转能力受损，其正镜像差异性消失。可为其早期临床诊断提供客观辅助指标。Objective To explore the brain electrophysiological mechanism of object rotation in first-epi- sode schizophrenia. Methods 30 patients with schizophrenia and 28 normal healthy people, who were from the Center for Mental Disease Control and Prevention,Third Hospital of PLA,took part in the mental rotation tasks, then the incubation period and amplitude of PS00, and the wrong number and reaction time were measured. Results Compared with control group （ normal ： （494.16± 34.68 ） ms, （ 9.56 ± 2.54） μV ; mirror ： （496.51 ± 33.10 ） ms, （ 6.38 ±2.41 ） μV） , schizophrenia＇incubation periods were significantly delayed （ normal ： （ 571.30 ± 51.21 ） ms ; mirror ： （ 573.41±39.27 ） ms ） and volatility were significantly lower （ normal ： （ 4.26 ± 1.01 ） μV ; mirror： （ 3.61± 1.21 ）μV） in normal and mirror rotation （P 〈 0.05 ）. The mirror-normal differences were not significant on the incubation periods of two groups （P 〉 0.05 ） ; the mirror-nomlal image differences were not significant on the patient group volatility （P〉0.05） ; the normal volatility was significantly higher than mirror in the control group （P 〈 0.05 ）. Conclusion Schizophrenia＇mental rotation ability is impaired, and mirror-normal differences on mental rotation are disappeared. It can be used as an early-stage clinical auxiliary diagnosis index.

关 键 词：精神分裂症 首发 客体旋转 事件相关电位 正镜像差异 

分 类 号：R971.4[医药卫生—药品]