兔中心型骺板缺损后骨桥切除的动物模型建立  

Building of the animal model of bone bridge resection in rabbits after making the center epiphyseal plate defects

作　　者：余黎[1] 余国荣[1] 张克勇 张桃根[1] 陶圣祥[1] 

机构地区：[1]武汉大学中南医院骨科,430071 [2]湖北省大冶市人民医院骨科

出　　处：《中华实验外科杂志》2012年第4期762-764,共3页Chinese Journal of Experimental Surgery

摘　　要：目的建立兔的股骨远端中心型骺板缺损后骨桥切除的动物模型，并对骨桥切除后的效果进行评价。方法选用日本大耳白兔10只，观察B—TcP与骨组织相容性及对骨桥生长影响。另取30只日本大耳白兔，分为A组（B—TcP标记＋骨桥切除＋脂肪填塞）、B组（B—TcP标记＋骨桥切除）、c组（单纯缺损），每组10只，评价B-TcP标记，导针引导的方法切除骨桥的手术效果。结果B．TcP置入后组织相容性良好，对骺板缺损后股骨畸形的程度没有影响（P〉0．05）；标记侧股骨长度（85．29±4．73）mm，外翻角度（12．35±2．53）°；未标记侧分别为（84．34±2．76）mm，（12．52±3．26）°。通过B—TcP标记，导针引导的方法可完整切除骨桥。运用脂肪筋膜瓣填塞骨桥切除后的缺损，可减轻股骨畸形的程度（P〈0．01）。A、B、c组的股骨短缩程度分别为（4．20±1．36）、（10．26±3．31）、（6．52±1．62）mm汐}翻角的差异分别为（12．00±2．11）°、（23．47±4．06）°、（18．38±10．65）°。结论通过0一TCP标记，导针引导的方法可建立兔股骨远端中心型骺板缺损后骨桥切除的标准动物模型。Objective To build the animal model of bone bridge resection in rabbits after making the center epiphyseal plate defects of distal femur and to evaluate the effectiveness of bone bridge resection. Methods The histocompatibility of β-TCP and its impact on the growth of bone bridge were observed in 10 Japanese white rabbits. The other 30 Japanese white rabbits were divided into three groups （ n = 10 for each） ： Group A （ β-TCP marker, bone bridge resection and fat filling） , Group B （ β-TCP marker and bone bridge resection） and Group C （simple defect）. The effect of bone bridge resection by the marker of β-TCP and the guidance of guide pin was evaluated. Results β-TCP had good biocompatibility after implantation and did not affect the degree of femoral deformity （P 〉 0. 05）. The average length of marked side＇ s femur was （ 85.29±4. 73 ） mm and the average valgus angle was （ 12. 35±2. 53 ） o. The unmarked sides were （84. 34±2. 76） mm and （12. 52±3.26）o respectively. By the marker of β-TCP and the guidance of guide pin, the bone bridge was removed completely. It reduced the degree of femoral deformity that the defects after bone bridge resection were filled with fat-fascia flap （P 〈 0. 01 ）. The femur shortening lengths of group A, B and C were （4. 20 ± 1.36 ）, （ 10. 26±3.31 ）, （6. 52±1.62） mm respectively, and the differences of valgus angles were （ 12. 00± 2. 11 ）°, （23.47 ±4. 06） °, （ 18. 38±10. 65 ） °. Conclusion The classic animal model of bone bridge resection in rabbits after making the center epiphyseal plate defects of distal femur can be established by the marker of β-TCP and the guidance of guide pin.

关 键 词：骺板 缺损 骨桥 动物模型 

分 类 号：R726.8[医药卫生—儿科]