养心康片对慢性心功能不全模型兔左室功能和ET-1的影响  

Effects of Yangxinkang Tablet on Left Ventricular Function and ET-1 of Rabbit Model with Chronic Heart Failure

作　　者：任培华[1] 冼绍祥[2] 杨忠奇[2] 陈洁[2] 

机构地区：[1]广州医学院第一附属医院,广东广州510120 [2]广州中医药大学第一附属医院,广东广州510405

出　　处：《辽宁中医药大学学报》2012年第4期76-78,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：广州市科技局资助项目(2008A1-E4101)

摘　　要：目的:观察养心康片对慢性心功能不全模型兔左室功能和ET-1的影响。方法:应用结扎兔冠状动脉的方法建立兔慢性心力衰竭的动物模型,随机分组后,分别给予相应的处理措施,连续4周。观察养心康片对心衰模型兔左室功能和内皮素-1(ET-1)的影响。结果:实验对照组的左室舒张末容积(LVEDV)最大,与中剂量组和高剂量组比较,其间差别有统计学意义(P<0.05)。实验对照组的左室射血分数(LVEF)值最低,与中剂量组和高剂量组比较,其间的差别有统计学意义(P<0.01)。实验对照组的ET-1值最高,与其他各组比较,其间的差别有统计学意义(P<0.01)。结论:养心康片可以改善心衰模型兔心功能,降低心衰模型兔血清ET-1的水平。To observe the effects of Yangxinkang tablet on left ventricular function and ET-1 of rabbit model with chronic heart failure. Method： Making heart failure animal model by blocking rabbit left anterior descending coronary artery. The experimental animals were divided into differen groups and were given appropriate treatment measures for 4 weeks. Investgated the effects of yangxinkang tablet on left ventricular function and ET-1 of rabbit model with heart failure. Result ： The LVEDd of experimental control group was maximum, compared with that of middle dose group and high dose group, the difference among them were statistically significant （ P〈0.05 ） .The LVEF of experimental control group was lowest, compared with that of middle dose group and high dose group, the differences among them were statistically significant （P〈0.01）. Comparison of ET-1 in each groups, the experimental control group was highest, compared with other groups, the differences among them were statistically significant （ P〈0.01 ）. Conclusion ： Yangxinkang tablet can improve cardiac function, reduce serum ET-1 levels of rabbit model with heart failure .

关 键 词：养心康片 慢性心功能不全 左室功能 ET-1 

分 类 号：R654.2[医药卫生—外科学]