Value of c-Met for Predicting Progression of Precancerous Gastric Lesions in Rural Chinese Population  

作　　者：YU Sun Meng-meng Tian Li-xin Zhou Wei-cheng You Ji-you Li 

机构地区：[1]Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education),Department of Pathology,Peking University School of Oncology,Beijing Cancer Hospital&Institute,Beijing 100142,China [2]Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education),Department of Epidemiology,Peking University School of Oncology,Beijing Cancer Hospital&Institute,Beijing 100142,China

出　　处：《Chinese Journal of Cancer Research》2012年第1期18-22,共5页中国癌症研究（英文版）

基　　金：supported by grants from Beijing Municipal Science & Technology Commission NOVA program (No. 2009BG-02);the National"863" High Technology Research and Development Program of China (No.2006AA02A402);the National "973" Major Basic Research Program of China (No. 2004CB518702)

摘　　要：Objective： To investigate the value of c-Met in predicting progression of precancerous gastric lesions. Methods： A population-based study was conducted to detect the overexpression of c-Met by immunohisto- chemical analysis in 124 subjects with precancerous gastric lesions. Odds ratio （OR） and 95% confidence interval （95% CI） were calculated for the association of c-Met overexpression with the risk of advanced gastric lesions. Results： The positive rates of c-Met were 55.7% in intestinal metaplasia （IM） and 64.8% in dysplasia （DYS）, respectively. Stratified analysis indicated that the proportion of c-Met overexpression was 71.4% for IM progressive group, significantly higher than that for IM persistent group （40.0%, P〈O.05）. Compared to the IM persistent group, unconditional logistic regression showed that OR of c-Met overexpression for the IM progressive group was 7.426 （95% Cl： 2.084-26.398）. Conclusion： c-Met plays an important role in gastric carcinogenesis. Detection of c-Met is of value in predicting progression of precancerous gastric lesions from IM to DYS.Objective： To investigate the value of c-Met in predicting progression of precancerous gastric lesions. Methods： A population-based study was conducted to detect the overexpression of c-Met by immunohisto- chemical analysis in 124 subjects with precancerous gastric lesions. Odds ratio （OR） and 95% confidence interval （95% CI） were calculated for the association of c-Met overexpression with the risk of advanced gastric lesions. Results： The positive rates of c-Met were 55.7% in intestinal metaplasia （IM） and 64.8% in dysplasia （DYS）, respectively. Stratified analysis indicated that the proportion of c-Met overexpression was 71.4% for IM progressive group, significantly higher than that for IM persistent group （40.0%, P〈O.05）. Compared to the IM persistent group, unconditional logistic regression showed that OR of c-Met overexpression for the IM progressive group was 7.426 （95% Cl： 2.084-26.398）. Conclusion： c-Met plays an important role in gastric carcinogenesis. Detection of c-Met is of value in predicting progression of precancerous gastric lesions from IM to DYS.

关 键 词：C-MET Intestinal metaplasia  Dysplasia FOLLOW-UP 

分 类 号：S831.5[农业科学—畜牧学] Q782[农业科学—畜牧兽医]