酰胺衍生寡聚DTPA钆配合物的合成、表征及弛豫性能  

Synthesis,Characterization and Relaxation Property of Oligomeric Gadolinium Complex Based on Amide Derivetives of DTPA

作　　者：郝志峰[1] 吴雅红[1] 汪朝阳[2] 黄卓亮[1] 余坚[1] 余林[1] 

机构地区：[1]广东工业大学轻工化工学院,广州510006 [2]华南师范大学化学与环境学院,广州510006

出　　处：《高等学校化学学报》2012年第4期663-667,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21101032);广东省自然科学基金(批准号:06021469)资助

摘　　要：以寡聚二乙撑三胺-N,N'-二(乙酰苯胺)-N,N',N″-三乙酸([H3L]n)为配体,与GdCl3在二甲基甲酰胺-水混合溶剂中组装得到了寡聚金属螯合物.采用傅里叶变换红外光谱(FTIR)、元素分析、核磁共振氢谱(1H NMR)和热重及差热分析(TG-DTA)确定了寡聚金属螯合物的组成单元为[GdL(H2O)]·4H2O,即寡聚配体的每个链节与1个金属离子配位.采用反转恢复法测试了寡聚金属螯合物和小分子配合物Gd-DTPA(DTPA为二乙撑三胺五乙酸)的纵向弛豫时间T1,该寡聚金属螯合物体外弛豫率为8.526 mmol·L-1·s-1,与配合物Gd-DTPA的弛豫率(4.370 mmol·L-1·s-1)相比,弛豫性能明显提高.An oligomeric complex was prepared via assembly reaction of oligomeric diethylenetriamine-N,N′-di（acetyl-p-aniline）-N,N′,N″-triacetic acid n with GdCl3 in DMF-H2O mixed solvent.The composition unit of the complex was confirmed to be [GdL（H2O）]·4H2O after characterized by Fourier transform infrared spectroscope（FTIR）,elemental analysis,1H NMR,thermal gravimetric and differential thermal analysis（TG-DTA）,which showed that every unit of the oligomeric ligand was coordinated to one metal ion.The longitudinal relaxivity time T1 of oligomeric Gd complex and Gd-DTPA（DTPA is diethylene triamine pentaacetic acid） were tested by inversion recovery.The results indicated that the relaxivity R1 of the oligomeric Gd complex was 8.526 mmol·L-1·s-1,which was greater than small molecular weight complex Gd-DTPA（4.370 mmol·L-1·s-1）.

关 键 词：酰化聚合反应 寡聚配合物 Gd(Ⅲ)配合物 弛豫性能 

分 类 号：O614.33[理学—无机化学]