手性药物(S)-布洛芬氢键自组装印迹聚合物识别机理  

Molecular Recognition Mechanism of Chiral(S)-Ibuprofen's Hydrogen Bonds Self-assembly Imprinted Polymer

作　　者：孙妍[1] 王兵[1] 

机构地区：[1]天津工业大学中空纤维膜材料与膜过程省部共建国家重点实验室培育基地,环境与化学工程学院,天津300160

出　　处：《高等学校化学学报》2012年第4期838-842,共5页Chemical Journal of Chinese Universities

基　　金：天津市自然科学基金重点项目(批准号:10JCZDJC21900)资助

摘　　要：以含有单一结合基团的手性药物(S)-布洛芬作为模板分子,制备了系列印迹聚合物.采用紫外-可见光谱和红外光谱对印迹及识别机理进行了研究.结果表明,模板分子与功能单体分别通过形成蓝移氢键和红移氢键完成预组装过程和再识别吸附过程,且形成了主客体配比为1∶1的配合物.等温吸附实验结果表明,印迹聚合物对模板分子表现出明显的选择性吸附,特异性吸附容量为37.92μmol/g,印迹指数为3.06,且印迹聚合物内特定的三维空间结构对其特异性吸附性能具有显著影响.由手性分离实验考察了印迹聚合物的拆分性能,其对(R)-布洛芬的分离因子为1.79.A series of imprinted polymer was synthesized using chiral（S）-ibuprofen with a single polarity group as the template molecular.The calculated results of UV indicated the complex ratio of host-guest was 1∶ 1.IR analysis result revealed in the pre-assembly process and re-adsorption process,the blue-shifted hydrogen bonds and red-shift hydrogen bonds were formed between template molecule and functional monomer,respectively.The isotherm results indicated that the specificity binding capacity was 37.92 μmol/g,and the imprinted factor of the polymer was 3.06.The chiral separation experiment indicated that compared with（R）-ibuprofen,（S）-ibuprofen template polymer exhibited significant adsorption selectivity for（S）-ibuprofen.Also,the separation factor was 1.79.

关 键 词：印迹机理 空间结构 氢键 印迹指数 (S)-布洛芬 

分 类 号：O631[理学—高分子化学] O657[理学—化学]