血浆网膜素-1在2型糖尿病合并缺血性心脏病中的变化及意义  

Change and significance of plasma omentin-1 in type 2 diabetes mellitus combined with ischemic heart disease

作　　者：翟倩倩[1] 李华[1] 杨再刚[1] 商丽娜[1] 冯涛[1] 田勇[2] 

机构地区：[1]郑州大学第一附属医院老年内分泌科,450052 [2]郑州人民医院特需科

出　　处：《中国实用医刊》2012年第7期49-51,共3页Chinese Journal of Practical Medicine

摘　　要：目的测定2型糖尿病（T2DM）伴缺血性心脏病患者血浆网膜素-1（Omentin—1）水平，探讨血浆Omentin-1与2型糖尿病并发缺血性心脏病的关系。方法收集70例男性2型糖尿病患者，按照是否伴有缺血性心脏病分为单纯2型糖尿病组36例（T2DM组）、2型糖尿病合并缺血性心脏病（IHD）组34例（T2DM＋IHD组）。另选取年龄相匹配的39例健康男性为对照组（NGT组）。三组均统计年龄、体质量指数（BMI）、空腹血糖（FBG）、糖化血红蛋白（HbA1C）、血清空腹胰岛素（Fins）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDL—C）、c-反应蛋白（CRP）及血浆Omentin—1、白细胞介素-6（IL-6）水平，计算LDIVHDL，并用稳态模型计算胰岛素抵抗指数（HOMA—IR）。应用SPSS17．0软件进行数据处理，组间比较采用t检验、方差分析。Omentin-1与其他指标的相关性应用Pearson相关分析、多元回归分析。结果T2DM组及T2DM＋IHD组患者血浆Omentin—I水平明显低于NGT组（P〈0．05）。血浆Omentin-1水平与BMI、HbA1c、HOMAH—IR、TG、LDL—C／HDL—C、IL-6呈负相关（P〈0．05），BMI、HOMA—IR、IL-6是影响血浆Omentin-1的独立危险因素（P=0．043，0．016，0．003）。结论血浆Omentin-1水平的改变与糖脂代谢及胰岛素抵抗有关，并可能参与了2型糖尿病合并缺血性心脏病的发生、发展。Objective To investigate the changes and implications of plasma omentin-1 level in type 2 diabetes mellitus combined with isehemic heart disease. Methods A total of seventy male pa- tients with type 2 diabetes mellitus were divided into two groups according to whether complicated with is- chaemic heart disease, another thirty-nine healthy male control subjects were enrolled in this study. Plas- ma levels of omentin-1 were measured by enzyme-linked immunosorbent assay. Results Plasma omentin- 1 levels were significantly decreased in patients with type 2 diabetes mellitus[ （1164±10）pg/mll and in patients with type 2 diabetes mellitus combined with ischaemic heart disease [ （393±10）pg/ml ]compared with healthy control [ （5764 ± 10）pg/ml, P 〈 0. 05 or 〈0. 01 ]. Plasma omentin-1 level was negatively correlated with BMI, HbAle, HOMAH,IR, TG, LDL-C/HDL-C, IL-6 （P 〈 0. 05）. Conclusions Chan- ges of plasma omentin-1 levels is related with glucose and lipid metabolism and insulin resistance, and it may involved in the pathogenesis of type 2 diabetes complicated with isehemic heart disease.

关 键 词：2型糖尿病 缺血性心脏病 OMENTIN-1 

分 类 号：R587.1[医药卫生—内分泌]