核黄素四丁酸酯抗焦虑作用的药效学研究  

Anxiolytic effects of riboflavin tetrabutyrate

作　　者：于文潇[1] 赵德[2] 邓君[1] 

机构地区：[1]西南大学药学院,重庆400716 [2]北大国际医院集团重庆大新药业股份有限公司,重庆400700

出　　处：《中国药理学通报》2012年第4期577-580,共4页Chinese Pharmacological Bulletin

摘　　要：目的考察核黄素四丁酸酯(RTB)的抗焦虑作用。方法以地西泮和丁螺环酮为阳性对照药,采用小鼠高架十字迷宫和新型食物消耗实验,评价RTB抗焦虑作用;采用转棒实验测定RTB对小鼠肌肉协调运动能力的影响。结果与空白对照组比较,RTB不影响小鼠在高架十字迷宫中的入臂总次数,但在20和40 mg.kg-1的剂量下明显增加开臂进入次数百分比和在开臂中滞留时间百分比;在新型食物消耗实验中,RTB在剂量为40和80 mg.kg-1时,明显增加小鼠单位体重的食物消耗量;转棒实验中,与阳性药物比较,RTB组明显降低了小鼠的跌落率。结论 RTB具有抗焦虑的作用,且不影响小鼠的活动能力和肌肉协调性。Aim To study anxiolytic effect of riboflavin tetrabutyrate（RTB）.Methods Mice were used as experimental animals and diazepam and buspirone as positive reference drugs.The anxiolytic effect of RTB was evaluated by elevated plus-maze（EPM） model and novel food consumption test.The effect of RTB on the muscle coordination was determined by RotaRod System.Results RTB did not influence the total entries into EPM arms of mice.However,at the dose of 20 and 40 mg·kg-1（po）,RTB increased the pecentages of OE and OT significantly in the model of EPM.At the dose of 40 and 80 mg·kg-1,RTB increased the consumption of novel food（mg·g-1） significantly.Meanwhile,RTB decreased the falling rate of mice from the rota-rod test in contrast with the positive reference drugs.Conclusion RTB has anxiolytic activity,but does not impair sports coordination.

关 键 词：核黄素四丁酸酯 抗焦虑 行为药理学 高架十字迷宫 新型食物消耗实验 转棒实验 

分 类 号：R965.1[医药卫生—药理学] R741[医药卫生—药学]