健康男性血浆kisspeptin与迟发性性腺功能减退关系研究  

The relationship between plasma kisspeptin levels and male menopause

作　　者：刘玥隽[1,2,3] 刘优萍[1,2,3] 杨军[1,2,3] 宁光[1,2,3] 李小英[1,2,3] 

机构地区：[1]上海交通大学医学院附属瑞金医院内分泌代谢科 [2]上海市内分泌代谢病临床医学中心 [3]上海市内分泌代谢病研究所,上海200025

出　　处：《中国实用内科杂志》2012年第4期294-296,共3页Chinese Journal of Practical Internal Medicine

基　　金：上海市科委重大子课题(09DJ1400402)

摘　　要：目的探讨健康男性血浆kisspeptin与更年期发生的关系。方法对上海市宝山区99名健康志愿者进行PADAM问卷调查、外周血激素测定,分析血浆kisspeptin与年龄、更年期发生及激素间的关系。结果成年男性99名血浆kisspeptin随年龄增加而增长,PADAM症状阳性率也随年龄增高。PADAM症状阳性组与阴性组间年龄差异有统计学意义(P<0.01),而kisspeptin差异无统计学意义(P>0.05)。血浆kisspeptin与年龄(P<0.01)、雌二醇(E2)(P=0.039)密切相关,年龄是血浆kisspeptin变化的重要影响因素(P=0.004)。结论血浆kisspeptin与更年期发生无明显关系,提示成年后kisspeptin在HPG轴中的作用可能不及青春期启动时重要。Objective To investigate the relationship between plasma kisspeptin levels and male menopause. Methods 99 male adults were recruited. Serum LH, FSH, T,iT, PRL, E2 and SHBG were measured by chemiluminescence analysis, and plasma kisspeptin by ELISA. The data was statistically analyzed using SPSS17. 0. The relationship of plasma kisspeptin lev- els with male menopause was investigated according to PADAM questionnaire. Results Plasma kisspeptin levels and the number of subjects with PADAM were increased with age. There was significant difference by age between PADAM and non- PADAM group（ P 〈 0. 01 ）, however, plasma kisspeptin levels were not significantly different in these two different groups （ P 〉 0.05 ）. Plasma kisspeptin levels were correlated with age （ P 〈 0.01 ） and serum E2 （ P = 0. 039 ） , but not with BMI, LH, FSH ,T,iT（ P 〉 0.05 ）. Age was also the only factor influencing plasma kisspeptin levels. Conclusion Plasma kisspep- tin levels were not associated with the male menopause ,which suggests that kisspeptin does not play a crucial role in regula- tion of HPG axis in adults.

关 键 词：迟发性性腺功能减退 GPR54 KISSPEPTIN 

分 类 号：R588.1[医药卫生—内分泌]