不同剂量hCG对体外受精-胚胎移植结局的影响  

Effect of different doses of human chorionic gonadotropin on the results of IVF

作　　者：陈霞[1] 赵军招[1] 王佩玉[1] 吴永根[1] 

机构地区：[1]温州医学院附属第一医院生殖中心,浙江温州325000

出　　处：《温州医学院学报》2012年第2期154-156,共3页Journal of Wenzhou Medical College

摘　　要：目的:探讨使用不同剂量人绒毛膜促性腺激素(hCG)对体外受精-胚胎移植(IVF-ET)的结局及对卵巢过度刺激综合征(OHSS)发病率的影响。方法:回顾性分析2007年6月至2011年6月在本中心接受IVF-ET的患者319例,采用促性腺激素释放激素激动剂(GnRH-a)/重组FSH(rFSH)/hCG长方案促排卵,按hCG用量分为A组(hCG用量:3 000 U)和B组(hCG用量:5 000 U)。观察两组获卵数目以及IVF结局等。结果:A、B两组的获卵数、成熟率、受精率差异均无统计学意义(均P>0.05),临床妊娠率分别为42.95%和46.47%(P>0.05),中重度OHSS发生率分别为4.69%和5.88%(P>0.05)。结论:超促排卵过程中减少使用hCG剂量对IVF-ET结局无明显影响。Objective： To evaluate the effects of different dose of human chorionic gonadotropin（hCG） on the results of in vitro fertilization（IVF） and the incidence of ovarian hyperstimulation syndrome（OHSS）.Methods： Three hundred and ninteen infetile women accepted IVF treatment during the period from June 2007 to June 2011 were analyzed retrospectively.A standard long protocol（GnRH-a/rFSH/hCG） was used for ovarian stimulation.These patients were divided into 2 groups： group A（hCG 3 000 U） and group B（hCG 5 000 U）.Results： There were no differences in number of oocytes retrieved,fertilization rates,cleavage rates after receiving different dose of hCG between two groups.The clinical pregnancy rates（42.95% vs.46.47%,P0.05） and the incidence of OHSS（4.69% vs.5.88%,P0.05） were obtained from group A and group B,respectively.Conclusion： Decreasing the dose of hCG do no affect on IVF outcomes.

关 键 词：人绒毛膜促性腺激素 卵巢过度刺激综合征 体外受精-胚胎移植 

分 类 号：R711.71[医药卫生—妇产科学]