呼吸道感染患儿肺炎支原体抗体检测结果分析  

Detection of antibody of Mycoplasma pneumonia in 7 023 children with respiratory infection in Shenyang area

作　　者：赵连爽[1] 赵俊华[2] 杜毅鑫[1] 康辉[1] 

机构地区：[1]中国医科大学附属第一医院检验科,辽宁沈阳110001 [2]中国医科大学临床医学七年制班

出　　处：《中国公共卫生》2012年第4期534-535,共2页Chinese Journal of Public Health

基　　金：辽宁省自然科学基金(20102267)

摘　　要：目的探讨血清肺炎支原体抗体IgM和IgG在沈阳地区呼吸道感染患儿的阳性检出率及其感染与年龄、性别和季节的关系。方法采用被动凝集法和金标免疫斑点法检测血清中肺炎支原体抗体,回顾分析2010年1-12月15岁以下7 023例呼吸道感染患儿肺炎支原体抗体IgM和IgG的检测结果。结果肺炎支原体抗体总阳性检出率为36.6%(2 569/7 023),IgM和IgG的阳性率分别为36.1(2 536/7 023)%和8.5%(597/7 023);不同性别间IgM差异有统计学意义(P<0.01);不同季节IgM阳性检出率差异有统计学意义(P<0.01),以秋季为最高,IgG以冬季为最高;血清IgM和IgG的阳性检出率各年龄组间差异均有统计学意义(P<0.01)。结论沈阳地区呼吸道感染患儿肺炎支原体感染占1/3以上,秋季多发,随着年龄增加,感染率逐渐增加,发病率女性高于男性。Objective To investigate the positive rate of anti-MP IgM＋ and anti-MP IgG＋ of Mycoplasma pneumonia（MP） in children with respiratory infection in Shenyang and the relationship between MP infection and age,gender,and season.Methods Passive particle agglutination and dot immunofiltration assay（DIFA） were used to detect serum anti-MP IgM and anti-MP IgG.Retrospective analysis was used for the measurement of anti-MP IgM and anti-MP IgG in 7 023 children under the age of 15 years with respiratory infection from Janaury to December,2010.Results The total positive rate of MP in the children was 36.6%（2 569/7 023）.The positive rate was 36.1% for anti-MP IgM（2 536/7 023）,with a significant difference between male and female（33.3% vs 39.5%,P〈0.01）.The positive rate was 8.5% for anti-IgG（597/7 023） without significant gender difference（P〈0.05）.The positive rate of anti-IgM in spring,summer,autumn,and winter was 29.0%,37.1%,38.9%,and 35.4%,respectively,with significant differences among the seasons（P〈0.01）.The positive rate of anti-IgM was the highest in autumn and that of anti-IgG was the highest in winter.The positive rate of anti-IgM in the newborn,baby,infant,preschool children,and school children was 2.6%,8.3%,20.6%,40.0%,and 44.9%,respectively,and that of anti-IgG was 0%,0.3%,3.5%,11.6%,and 9.7%,respectively,with significant differences among the different groups（P〈0.01 for all）.Conclusion Mycoplasma pneumonia infection accounts for more than one third of respiratory infection in the children and is the most common in autumn.The children less than one year old have the lowest positive rate.The positive rate increases with the age of children and the morbidity is higher in the female.

关 键 词：肺炎支原体 抗体 儿童 呼吸道感染 

分 类 号：R183.3[医药卫生—流行病学]