甲状腺功能正常者甲状腺激素水平与冠心病发病的相关性分析  

Thyroid hormone level in coronary heart disease patients with euthyroidism

作　　者：赵翠[1] 曹路[2] 丛洪良[2] 

机构地区：[1]天津医科大学研究生院,300070 [2]天津市胸科医院心内四科

出　　处：《中华老年心脑血管病杂志》2012年第4期358-360,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：天津市卫生局重点科技基金(10KG121)

摘　　要：目的探讨正常值范围内的甲状腺激素水平与冠心病发病的相关性。方法将485例甲状腺功能正常且接受冠状动脉造影检查的住院患者,根据造影结果分为冠心病组247例,非冠心病组238例,比较2组甲状腺激素水平,并探讨甲状腺激素水平与冠心病发病的相关性。结果与非冠心病组比较,冠心病组血清游离三碘甲状腺原氨酸(FT_3)水平明显降低(P<0.05);2组三碘甲状腺原氨酸、甲状腺素、游离甲状腺素、促甲状腺素水平差异无统计学意义(P>0.05);多变量logistic逐步回归分析显示,血清FT_3水平降低是冠心病发生的危险因素(OR=0.449,P<0.05)。结论甲状腺功能正常的冠心病患者较非冠心病患者血清FT_3水平偏低,较低水平FT_3可作为冠心病的独立危险因素。Objeetive To study the correlation between normal level of thyroid hormone and indicidence of coronary heart disease（CHD）. Methods Four hundred and eighty-five patients with euthyroidism were divided into CHD group （n = 247） and non-CHD group（control group, n= 238） according to their angiography findings. Their thyroid hormone levels were compared and correlation between thyroid hormone level and CHD was studied. Results The serum free triiodothyronine（FTa ） level was significantly lower in CHD group than in control group（P〈0.05）. No significant difference was found in the levels of triiodothyronine,thyronine,free thyronine and thyroid stimulating hormone between the two groups（P〉0.05）. Multivariate logistic regression analysis showed that the lower serum FTa level was an independent risk factor for CHD（OR=0. 449,P〈 0.05）. Conclusion The serum FTa level is lower in CHD patients with euthyroidism than in non- CHD patients, which is an indepent risk factor for CHD.

关 键 词：甲状腺功能减退症 冠心病 甲状腺激素类 三碘甲状腺原氨酸 冠状血管造影术 危险因素 

分 类 号：R541.4[医药卫生—心血管疾病]