疏血通与丹参对脑梗死患者及其高危人群血液流变学影响的Meta分析  

A Meta-analysis for hemorrheologic parameters in patients with cerebral infarction or high risk population treated by Shuxuetong or Danshen

作　　者：颜陶[1] 周岐新[1] 费慧芝[1] 胡小娅[1] 杨秋珺[1] 

机构地区：[1]重庆医科大学药学院药理学教研室,重庆400016

出　　处：《中国临床药理学与治疗学》2012年第3期302-307,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:比较疏血通与丹参在改善脑梗死患者及其高危人群血流状态的差异,为临床用药提供循证医学依据。方法:通过检索2000-2011年国内发表的文献,按纳入排除标准筛选,得到符合研究条件的文献13篇,用Meta分析方法处理文献中的数据。结果:疏血通组与丹参组比较:全血高切黏度(mPa.s):WMD=-0.53,95%CI(-0.76,-0.31),P<0.05;全血低切黏度(mPa.s):WMD=-1.40,95%CI(-2.05,-0.74),P<0.05;血浆黏度(mPa.s):WMD=-0.27,95%CI(-0.39,-0.15),P<0.05;纤维蛋白原(g/L):WMD=-0.75,95%CI(-0.97,-0.52),P<0.05;红细胞压积:WMD=-0.05,95%CI(-0.08,-0.01),P<0.05。结论:疏血通对血液流变学各项指标的影响均优于丹参,但文献的异质性较大。To compare effects of Shux- uetong on hemorrheologic parameters to that of Danshen in patients with cerebral infarction orhigh risk population, so that evidences in Evi- dence-based Medicine can be provided for clinical pharmacotherapy. METHODS. Thirteen articlescorresponding to our researching condition were searched out by retrieving and screening domes- tic articles from 2000 to 2011 according to the criterion for including or excluding articles. The data were processed by the method of meta anal ysis. RESULTS：A comparison between Shuxue- tong versus Danshen. Hs[WMD=-0.53,95%CI（-0.76,-0.31）,Pd0.05]; LS [WMI）=-1.40, 95%CI （-2.05, -0.71）, P 〈0.05]; PV EWMD=-0.27, 95%CI （- 0.39, -0.15）, P〈0.05%; FIB [WMD=- 0.75. 95%CI （-0.97, -0.52）, P〈0. 05];HCT W[MI）= -0.05. 95%CI （-0.08. - 0.01）, P〈 0.051. CONCLUSION： The im- provement effects of Shuxuetong on hemorrheo- logic parameters are better than that of Dansh- en, even though serious heterogeneity exists a- mong the selected articles.

关 键 词：疏血通 丹参 血液流变学 脑梗死 高 危 META分析 循证医学 

分 类 号：R969.3[医药卫生—药理学] R285.6[医药卫生—药学]