汉防己甲素聚乳酸微球的安全性评价  

Safety Evaluation of Tetrandrine Polylactic Acid Microspheres

作　　者：胡泽丽[1] 程国华[1] 庞廷媛[1] 陈娟[1] 汪小乐[1] 

机构地区：[1]广州医学院附属肿瘤医院药剂科,广州510095

出　　处：《中国药房》2012年第15期1361-1363,共3页China Pharmacy

基　　金：广州市科技三项项目(2006Z3-E4121)

摘　　要：目的:评价汉防己甲素聚乳酸微球(TET-MC)的安全性。方法:采用液中干燥法制备TET-MC,对TET-MC进行急性毒性、血管刺激性、肌肉刺激性、过敏性试验。结果:小鼠静脉注射TET-MC的半数致死量为158.9mg·kg-1;未观察到TET-MC对实验动物有血管刺激性、过敏性,但有轻微的肌肉刺激性。结论:汉防己甲素微球化后毒性降低,应用于受试动物安全性较好。OBJECTIVE：To evaluate the safety of Polylactic acid microspheres（TET-MC）.METHODS：The in-liquid drying was used to prepare TET-MC.The acute toxicity LD50 test,venous and muscular stimulation test,allergic test in vitro were conducted.RESULTS：The value of LD50 for mice with intravenous injection was 158.9 mg·kg-1.There was slight muscle stimulating,but no veins stimulating,allergic reactions.CONCLUSION：Toxicity of TET is decreased by microsphere and TET-MC is basically safe.

关 键 词：汉防己甲素 微球 急性毒性 安全性 

分 类 号：R965.3[医药卫生—药理学]