正交试验优选姜黄素明胶微球的处方工艺  

Optimization of the Formulation Technology of Curcumin Gelatin Microspheres by Orthogonal Test

作　　者：邓航[1] 陈薇[1] 黄桂红[1] 李江[1] 邓俊刚[1] 

机构地区：[1]桂林医学院附属医院,广西桂林541001

出　　处：《中国药房》2012年第15期1378-1379,共2页China Pharmacy

基　　金：广西科学研究与技术开发计划项目(桂科攻0999003);广西医疗卫生重点科研课题(重2010054)

摘　　要：目的:优选姜黄素明胶微球的最佳处方工艺。方法:以明胶浓度、油水比例、乳化时间为考察因素,以载药量、包封率、微球粒径为评价指标,以明胶为载体,采用正交试验优选乳化交联法制备姜黄素明胶微球的处方工艺。结果:优选的处方工艺要求油水比为1:5,明胶浓度为25%,乳化时间为30min。结论:该处方工艺稳定、可行,重现性好,可为姜黄素明胶微球的后续研究提供理论依据。OBJECTIVE：To study the best preparation technology of Curcumin gelatin microspheres.METHODS：Emulsion chemical cross-linking method for the preparation of Curcumin gelatin microspheres was optimized by orthogonal experiment using gelatin concentration,oil/water ratio and emulsification time as factors with drug-loading amount,encapsulation coefficency and particle size as index using gelatin as carrier.RESULTS：The optimal formulation technology of Curcumin gelatin microspheres was as follows：the ratio of water to oil was 1：5,the concentrarion of gelatin was 25% and the emulsification time was 30 min.CONCLUSION：The formulation technology is stable,feasible and reproducible,and it provides theoretic basis for the further study of Curcumin gelatin microspheres.

关 键 词：姜黄素 明胶 微球 肺靶向 

分 类 号：R283.62[医药卫生—中药学] R94[医药卫生—中医学]