新血府逐瘀汤对动脉粥样硬化模型大鼠外周血IgG和C3、C4的影响  

Influence of new Xuefuzhuyu decoction on IgG and C3, C4 of peripheral blood in atherosclerosis rat

作　　者：王威霖[1] 吉中强[2] 王咏[1] 马善村[1] 纪文岩[2] 

机构地区：[1]山东中医药大学2005级七年制硕士研究生,济南250014 [2]青岛海慈医疗集团中医心内科,266033

出　　处：《国际中医中药杂志》2012年第4期321-323,共3页International Journal of Traditional Chinese Medicine

摘　　要：目的探讨新血府逐瘀汤对动脉粥样硬化（atherosclerosis，AS）大鼠外周血免疫球蛋白IgG和补体c3、C4的影响。方法选取健康成年Wister大鼠，按随机数字表法分为空白组、AS模型组、新血府逐瘀汤低剂量组、新血府逐瘀汤高剂量组和阳性对照组各13只，采用维生素D3联合高脂饲料的方法制作动脉粥样硬化大鼠模型，实验第1天开始药物灌胃，新血府逐瘀汤低剂量组给予新血府逐瘀汤（0．6g／m1）、新血府逐瘀汤高剂量组给予新血府逐瘀汤（1．2g／m1）、阳性对照组给予阿托伐他汀、空白组于AS模型组给予蒸馏水各15ml／kg·d1灌胃。各组每周称重1次，根据体重调整灌胃量，连续灌胃8周。腹主动脉取血，采用免疫散射比浊法测定IgG、C3、C4。结果AS模型组血清中IgG、C3、C4含量[分别为（8．110±0．720）g/L、（1．591±0．143）g／L、（0．390±O．33）g／L]，新血府逐瘀汤低剂量组[分别为（8．000±O．840）g／L、（1．564±0．132）g／L、（0．396±0．36）g／L]，新血府逐瘀汤高剂量组[分别为（7．250±0．740）g／L、（1．390±0．150）g／L、（0．326±0．153）g／L]，阳性对照组[分别为（7．240±0．400）g／L、（1．414±0．104）g/L、（0．330±0．164）g／L]，均高于空白组[分别为（5．810±0．820）g／L、（0．943±0．124）g／L、（0．330±0．164）g／L]，差异有统计学意义（P均〈0．05）。新血府逐瘀汤高剂量组、阳性对照组各项均低于模型组、新血府逐瘀汤低剂量组，差异均有统计学意义（P均〈0．05）。新血府逐瘀汤高剂量组与阳性对照组各项分别比较，差异无统计学意义（P〉0．05）。结论新血府逐瘀汤对动脉粥样硬化模型大鼠外周血IgG、C3、C4有改善作用，效果与阿托伐他汀相仿。Objective To explore the influence of new Xuefuzhuyu decotion on lgG, C3 and C4 of peripheral blood in atheroselerosis rats. Methods Healthy adult Wister rats were selected and randomly divided into blank group, AS model group, new Xuefuzhuyu decoctioin low dosage group, the new Xuefuzhuyu decoctioin high dosage group, and positive control group, with 13 cases in each group. Vitamin D3 joint high fat feeding method was adopted to establish atherosclerosis rat model. Medicine lavage began on the first day of experiment. Low dosage new Xuefuzhuyu decoctioin, high dosage new Xuefuzhuyu decoctioin, and atovastatin were administrated to the new Xuefuzhuyu decoctioin low dosage group, the new Xuefuzhuyu decoctioin high dosage group, and positive control group respectively, and distilled water 15 ml/kg ~ d-1 was administrated to both the blank group and the AS model group. The weight of body was detected each week in each group for regulating the administrated dosage. After medicine lavage was performed for successive 8 weeks, blood was obtained from abdominal aorta for detecting IgG C3, C4 by immune scattering method. Results The value of IgG C3 and C4 were （8.110±0.720）g/L, （1.591±0.143）g/L, （0.390±0.33）g/L in the AS model group, （8.000±0.840）g/L, （1.564±0.132）g/L, （0.396±0.36）g/L new Xuefuzhuyu decoctioin low dosage group, （7.250 ± 0.740） g/L, （1.390± 0.150） g/L, （0.326±0.153） g/L new XuefiLzhuyu decoctioin high dosage group and （7.240±0.400） g/L, （1.414± 0.104） g/L, （0.330± 0.164） g/L in the positive control group, all of which werehigher than the blank group （5.810±0.820）g/L, （0.94±0.124）g/L, （0.330＋0.164）g/L with statistically significant difference （P〈0.05）. Each value of IgG C3 and C4 in the new Xuefuzhuyu decoctioin high dosage group and the positive control group were lower than the AS model group and the new Xuefuzhuyu decoctioin low dosage group, with a statistically significant difference（P〈0.05）.There was no significan

关 键 词：新血府逐瘀汤 动脉粥样硬化 免疫球蛋白IGG 补体C3 补体C4 

分 类 号：R285.5[医药卫生—中药学]